Evaluation of Ocular Surface Health in Patients with Obstructive Sleep Apnea Syndrome

Overview

Journal Turk J Ophthalmol

Specialty Ophthalmology

Date 2016 Nov 2

PMID 27800271

Citations 14

Authors

Emine Esra Karaca

Hanife Tuba Akcam

Feyzahan Uzun

Sengul Ozdek

Tansu Ulukavak Ciftci

Affiliations

Soon will be listed here.

Abstract

Objectives: To evaluate ocular surface health in obstructive sleep apnea syndrome (OSAS) and to investigate the tendency of these patients toward dry eyes.

Materials And Methods: Fifty patients who underwent polysomnography and were diagnosed with OSAS and 50 normal control subjects were compared with respect to ocular surface disease index (OSDI), Schirmer I test and tear film break-up time (TBUT) values.

Results: Patients were grouped as mild (n=15, 30%), moderate (n=15, 30%) and severe (n=20, 40%) according to apnea-hypopnea index values. The right eyes of patients were included in both groups. OSDI values were as follows: control group, 18.7±8.5; mild OSAS group, 40.2±2.8; moderate OSAS group, 48.5±2.2 and severe OSAS group, 62.7±2.3 (p<0.001). TBUT values were as follows: control group, 12.3±4.9; mild OSAS group, 8.2±4.7; moderate OSAS group, 5.8±2.1 and severe OSAS group, 4.2±3.7 (p<0.001). Schirmer values were as follows: control group, 18±6.1 mm; mild OSAS group, 12.9±6.7 mm; moderate OSAS group, 8.5±5.2 mm and severe OSAS group, 7.9±4.7 mm (p<0.001).

Conclusion: Patients with OSAS seem to have a tendency toward dry eyes. Clinicians should be aware of dry eye development in these patients.

Citing Articles

Impact of Obstructive Sleep Apnea and Continuous Positive Airway Pressure Treatment on Dry Eye Disease: A Systematic Review and Meta-Analysis.

Lin C, Su Y, Liu J, Su H, Chiang T, Chiu L Nat Sci Sleep. 2024; 16:1921-1935.

PMID: 39659892 PMC: 11629664. DOI: 10.2147/NSS.S495883.

Ocular Surface Assessment in Patients with Obstructive Sleep Apnea Syndrome.

Ghaffari R, Ghassemi H, Sadeghniiat Haghighi K, Zarei-Ghanavati M, Latifi G, Nebi Kheder K J Curr Ophthalmol. 2024; 36(1):42-45.

PMID: 39553316 PMC: 11567611. DOI: 10.4103/joco.joco_173_23.

Associations Between Obstructive Sleep Apnea Syndrome, Dry Eye Disease, and CPAP Usage Among Taiwanese Patients: A Retrospective Analysis.

Fu Y, Sun C, Chen K, Lin Y, Chang C, Chang S Nat Sci Sleep. 2024; 16:1001-1009.

PMID: 39050364 PMC: 11268847. DOI: 10.2147/NSS.S458245.

Effect of chronic intermittent hypoxia on ocular and intraoral mechanical allodynia mediated via the calcitonin gene-related peptide in a rat.

Katagiri A, Kishimoto S, Okamoto Y, Yamada M, Niwa H, Bereiter D Sleep. 2024; 47(3).

PMID: 38166171 PMC: 10925949. DOI: 10.1093/sleep/zsad332.

Ocular manifestations in COVID-19 infections: a case series.

Khalayli N, Haider G, Hodifa Y, Kudsi M, Naman N Ann Med Surg (Lond). 2023; 85(11):5309-5313.

PMID: 37915673 PMC: 10617833. DOI: 10.1097/MS9.0000000000001305.

References

Rolando M, Zierhut M . The ocular surface and tear film and their dysfunction in dry eye disease. Surv Ophthalmol. 2001; 45 Suppl 2:S203-10. DOI: 10.1016/s0039-6257(00)00203-4. View

Akpek E, Klimava A, Thorne J, Martin D, Lekhanont K, Ostrovsky A . Evaluation of patients with dry eye for presence of underlying Sjögren syndrome. Cornea. 2009; 28(5):493-7. PMC: 2693267. DOI: 10.1097/ICO.0b013e31818d3846. View

Mojon D, Hess C, Goldblum D, Fleischhauer J, Koerner F, Bassetti C . High prevalence of glaucoma in patients with sleep apnea syndrome. Ophthalmology. 1999; 106(5):1009-12. DOI: 10.1016/S0161-6420(99)00525-4. View

Wang T, Wang I, Hu C, Lin H . Comorbidities of dry eye disease: a nationwide population-based study. Acta Ophthalmol. 2010; 90(7):663-8. DOI: 10.1111/j.1755-3768.2010.01993.x. View

Karger R, White W, Park W, Rosales A, McLaren J, Olson E . Prevalence of floppy eyelid syndrome in obstructive sleep apnea-hypopnea syndrome. Ophthalmology. 2006; 113(9):1669-74. DOI: 10.1016/j.ophtha.2006.02.053. View

Culbertson W, Ostler H . The floppy eyelid syndrome. Am J Ophthalmol. 1981; 92(4):568-75. DOI: 10.1016/0002-9394(81)90652-8. View

Negris R . Floppy eyelid syndrome associated with keratoconus. J Am Optom Assoc. 1992; 63(5):316-9. View

Li J, McGwin Jr G, Vaphiades M, Owsley C . Non-arteritic anterior ischaemic optic neuropathy and presumed sleep apnoea syndrome screened by the Sleep Apnea scale of the Sleep Disorders Questionnaire (SA-SDQ). Br J Ophthalmol. 2007; 91(11):1524-7. PMC: 2095405. DOI: 10.1136/bjo.2006.113803. View

Bilenchi R, Poggiali S, Pisani C, De Aloe G, Motolese P, Motolese E . Floppy eyelid syndrome associated with obstructive sleep apnoea. Br J Dermatol. 2004; 151(3):706. DOI: 10.1111/j.1365-2133.2004.06153.x. View

10.

Tseng S, Tsubota K . Important concepts for treating ocular surface and tear disorders. Am J Ophthalmol. 1997; 124(6):825-35. DOI: 10.1016/s0002-9394(14)71700-3. View

11.

McNab A . Floppy eyelid syndrome and obstructive sleep apnea. Ophthalmic Plast Reconstr Surg. 1997; 13(2):98-114. DOI: 10.1097/00002341-199706000-00005. View

12.

Hayirci E, Yagci A, Palamar M, Basoglu O, Veral A . The effect of continuous positive airway pressure treatment for obstructive sleep apnea syndrome on the ocular surface. Cornea. 2012; 31(6):604-8. DOI: 10.1097/ICO.0b013e31824a2040. View

13.

Ozcura F, Aydin S, Helvaci M . Ocular surface disease index for the diagnosis of dry eye syndrome. Ocul Immunol Inflamm. 2007; 15(5):389-93. DOI: 10.1080/09273940701486803. View

14.

Pflugfelder S, Solomon A, Stern M . The diagnosis and management of dry eye: a twenty-five-year review. Cornea. 2000; 19(5):644-9. DOI: 10.1097/00003226-200009000-00009. View

15.

Guilleminault C, Abad V . Obstructive sleep apnea syndromes. Med Clin North Am. 2004; 88(3):611-30, viii. DOI: 10.1016/j.mcna.2004.01.002. View

16.

Culbertson W, Tseng S . Corneal disorders in floppy eyelid syndrome. Cornea. 1994; 13(1):33-42. DOI: 10.1097/00003226-199401000-00007. View

17.

Mojon D, Goldblum D, Fleischhauer J, Chiou A, Frueh B, Hess C . Eyelid, conjunctival, and corneal findings in sleep apnea syndrome. Ophthalmology. 1999; 106(6):1182-5. DOI: 10.1016/S0161-6420(99)90256-7. View

18.

Ulukavak Ciftci T, Kokturk O, Bukan N, Bilgihan A . The relationship between serum cytokine levels with obesity and obstructive sleep apnea syndrome. Cytokine. 2004; 28(2):87-91. DOI: 10.1016/j.cyto.2004.07.003. View

19.

Jindal M, Hiam L, Raman A, Rejali D . Idiopathic intracranial hypertension in otolaryngology. Eur Arch Otorhinolaryngol. 2009; 266(6):803-6. DOI: 10.1007/s00405-009-0973-0. View

20.

Acar M, Firat H, Acar U, Ardic S . Ocular surface assessment in patients with obstructive sleep apnea-hypopnea syndrome. Sleep Breath. 2012; 17(2):583-8. DOI: 10.1007/s11325-012-0724-0. View