Serum C-Reactive Protein in Children with Liver Disease and Ascites

Overview

Journal Hepat Mon

Publisher Brieflands

Specialty Gastroenterology

Date 2016 Nov 1

PMID 27795726

Citations 2

Authors

Gholamreza Kalvandi

Naser Honar

Bita Geramizadeh

Maryam Ataollahi

Asghar Rahmani

Hazhir Javaherizadeh

Affiliations

Soon will be listed here.

Abstract

Background: The diagnosis of peritonitis as a complication of cirrhosis is an important clinical problem.

Objectives: The aim of this study was to evaluate serum C-reactive protein levels as a diagnostic factor for spontaneous bacterial peritonitis (SBP) in child patients with liver disease.

Methods: In this study, 150 children diagnosed with liver disease and ascites upon admission to Nemazee Teaching Hospital (Shiraz, Iran) were examined. Patients were divided into spontaneous bacterial peritonitis and sterile ascetic fluid groups according to the PMN count ≥ 250/mm in the ascetic fluids. Routine laboratory tests were conducted and quantitative C-reactive protein (CRP) levels were measured for all of the patients. Accuracy, sensitivity, and specificity of CRP was evaluated for diagnosis of SBP.

Results: Of 150 cirrhotic patients, 109 patients presented without SBP (52.29% male, mean age: 5.02 ± 4.49 years) and 41 patients presented with SBP (51.21% male, mean age: 4.71 years). Cell counts, protein levels, albumin levels, and lactate dehydrogenize (LDH) levels of the ascetic fluid and serum samples in the SBP group were higher than the rates for those without SBP (P < 0.05(. The mean ± SD of CRP in the SBP group (36.89 ± 23.43) increased significantly compared to the rate among those without SBP (21.59 ± 15.43, P = 0.001). The percentages for sensitivity and specificity of CRP, the diagnosis of SBP based on the PMN count ≥ 250/mm, and cultured ascites were 69.23%, 90.25%, 88.43%, and 84.32%, respectively. The areas under the curve of CRP for SBP based on the PMN count ≥ 250/mm and cultured ascites was 0.94 (CI 95%: 0.90 to 0.96) and 0.85 (CI 95%: 0.84 to 0.92), respectively (P < 0.001).

Conclusions: Our study showed that CRP is a marker with high sensitivity and specificity for the diagnosis of SBP in cirrhotic children.

Citing Articles

Routine analysis of ascitic fluid for evidence of infection in children with chronic liver disease: Is it mandatory?.

Ghobrial C, Mogahed E, El-Karaksy H PLoS One. 2018; 13(10):e0203808.

PMID: 30289914 PMC: 6173381. DOI: 10.1371/journal.pone.0203808.

Spontaneous bacterial and fungal peritonitis in patients with liver cirrhosis: A literature review.

Shizuma T World J Hepatol. 2018; 10(2):254-266.

PMID: 29527261 PMC: 5838444. DOI: 10.4254/wjh.v10.i2.254.

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