Nitrogen-Containing Constituents of Black Cohosh: Chemistry, Structure Elucidation, and Biological Activities

Overview

Journal Recent Adv Phytochem

Specialty Chemistry

Date 2015 Jan 1

PMID 27795590

Citations 12

Authors

Dejan Nikolic

David C Lankin

Tamara Cisowska

Shao-Nong Chen

Guido F Pauli

Richard B van Breemen

Affiliations

Soon will be listed here.

Abstract

The roots/rhizomes of black cohosh ( L. syn. [L]. Nutt., Ranunculaceae) have been used traditionally by Native Americans to treat colds, rheumatism, and a variety of conditions related to women's health. In recent years black cohosh preparations have become popular dietary supplements among women seeking alternative treatments for menopausal complaints. The popularity of the plant has led to extensive phytochemical and biological investigations, including several clinical trials. Most of the phytochemical and biological research has focused on two abundant classes of compounds: the triterpene glycosides and phenolic acids. A third group of phytoconstituents that has received far less attention consists of the alkaloids and related compounds that contain nitrogen. This chapter summarizes the current state of knowledge of the chemistry and biological activities associated with this group of constituents and provides some perspective on their significance for future research on this interesting plant.

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