Multimerization of the Virulence-Enhancing Group A Streptococcus Transcription Factor RivR Is Required for Regulatory Activity

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 2016 Nov 1

PMID 27795318

Citations 4

Authors

Anupama Ramalinga

Jessica L Danger

Nishanth Makthal

Muthiah Kumaraswami

Paul Sumby

Affiliations

Soon will be listed here.

Abstract

Importance: The modulation of gene transcription is key to the ability of bacterial pathogens to infect hosts to cause disease. Here, we discovered that the group A Streptococcus transcription factor RivR negatively regulates the ability of this pathogen to survive in human blood, and we also began biochemical characterization of this protein. We determined that, in order for RivR to function, it must self-associate, forming both dimers (consisting of two RivR proteins) and higher-order complexes (consisting of more than two RivR proteins). This functional requirement for RivR is shared by other regulators in the same family of proteins, suggesting a common regulatory mechanism. Insight into how these transcription factors function may facilitate the development of novel therapeutic agents targeting their activity.

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