FoxO1: a Novel Insight into Its Molecular Mechanisms in the Regulation of Skeletal Muscle Differentiation and Fiber Type Specification

Overview

Journal Oncotarget

Specialty Oncology

Date 2016 Oct 30

PMID 27793012

Citations 54

Authors

Meng Xu

Xiaoling Chen

Daiwen Chen

Bing Yu

Zhiqing Huang

Affiliations

Soon will be listed here.

Abstract

FoxO1, a member of the forkhead transcription factor forkhead box protein O (FoxO) family, is predominantly expressed in most muscle types. FoxO1 is a key regulator of muscle growth, metabolism, cell proliferation and differentiation. In the past two decades, many researches have indicated that FoxO1 is a negative regulator of skeletal muscle differentiation while contrasting opinions consider that FoxO1 is crucial for myoblast fusion. FoxO1 is expressed much higher in fast twitch fiber enriched muscles than in slow muscles and is also closely related to muscle fiber type specification. In this review, we summarize the molecular mechanisms of FoxO1 in the regulation of skeletal muscle differentiation and fiber type specification.

Citing Articles

Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice.

Sun S, Yu T, Huh J, Cai Y, Yoon S, Javaid H Skelet Muscle. 2025; 15(1):2.

PMID: 39806512 PMC: 11726948. DOI: 10.1186/s13395-024-00371-1.

Dysregulated FOXO1 activity drives skeletal muscle intrinsic dysfunction in amyotrophic lateral sclerosis.

Zufiria M, Pikatza-Menoio O, Garciandia-Arcelus M, Bengoetxea X, Jimenez A, Elicegui A Acta Neuropathol. 2024; 148(1):43.

PMID: 39283487 PMC: 11405449. DOI: 10.1007/s00401-024-02794-y.

IGF-I concentration determines cell fate by converting signaling dynamics as a bifurcation parameter in L6 myoblasts.

Okino R, Mukai K, Oguri S, Masuda M, Watanabe S, Yoneyama Y Sci Rep. 2024; 14(1):20699.

PMID: 39237579 PMC: 11377782. DOI: 10.1038/s41598-024-71739-y.

Sucrose-induced metabolic syndrome differentially affects energy metabolism and fiber phenotype of EDL and soleus muscles during exercise in the rat.

Eduardo R, Karla C Physiol Rep. 2024; 12(13):e16126.

PMID: 39001594 PMC: 11245568. DOI: 10.14814/phy2.16126.

Investigation of single nucleotide polymorphisms in differentially expressed genes and proteins reveals the genetic basis of skeletal muscle growth differences between Tibetan and Large White pigs.

Xiong H, Zhang Y, Zhao Z Anim Biosci. 2024; 37(12):2021-2032.

PMID: 38938033 PMC: 11541014. DOI: 10.5713/ab.24.0135.

References

Castrillon D, Miao L, Kollipara R, Horner J, DePinho R . Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science. 2003; 301(5630):215-8. DOI: 10.1126/science.1086336. View

Rochat A, Fernandez A, Vandromme M, Moles J, Bouschet T, Carnac G . Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy. Mol Biol Cell. 2004; 15(10):4544-55. PMC: 519148. DOI: 10.1091/mbc.e03-11-0816. View

Nakae J, Barr V, Accili D . Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR. EMBO J. 2000; 19(5):989-96. PMC: 305638. DOI: 10.1093/emboj/19.5.989. View

Kamei Y, Miura S, Suzuki M, Kai Y, Mizukami J, Taniguchi T . Skeletal muscle FOXO1 (FKHR) transgenic mice have less skeletal muscle mass, down-regulated Type I (slow twitch/red muscle) fiber genes, and impaired glycemic control. J Biol Chem. 2004; 279(39):41114-23. DOI: 10.1074/jbc.M400674200. View

Lara-Pezzi E, Winn N, Paul A, McCullagh K, Slominsky E, Santini M . A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration. J Cell Biol. 2007; 179(6):1205-18. PMC: 2140042. DOI: 10.1083/jcb.200704179. View

Lai E . Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins. EMBO Rep. 2002; 3(9):840-5. PMC: 1084223. DOI: 10.1093/embo-reports/kvf170. View

Nakae J, Kitamura T, Kitamura Y, Biggs 3rd W, Arden K, Accili D . The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev Cell. 2003; 4(1):119-29. DOI: 10.1016/s1534-5807(02)00401-x. View

Meriane M, Roux P, Primig M, Fort P, Gauthier-Rouviere C . Critical activities of Rac1 and Cdc42Hs in skeletal myogenesis: antagonistic effects of JNK and p38 pathways. Mol Biol Cell. 2000; 11(8):2513-28. PMC: 14936. DOI: 10.1091/mbc.11.8.2513. View

Okada K, Naito A, Higo T, Nakagawa A, Shibamoto M, Sakai T . Wnt/β-Catenin Signaling Contributes to Skeletal Myopathy in Heart Failure via Direct Interaction With Forkhead Box O. Circ Heart Fail. 2015; 8(4):799-808. DOI: 10.1161/CIRCHEARTFAILURE.114.001958. View

10.

Li X, Liu H, Wang H, Sun L, Ding F, Sun W . Follistatin could promote the proliferation of duck primary myoblasts by activating PI3K/Akt/mTOR signalling. Biosci Rep. 2014; 34(5). PMC: 4201216. DOI: 10.1042/BSR20140085. View

11.

Jung J, Kim T, Lyons G, Kim H, Lee Y . Jumonji regulates cardiomyocyte proliferation via interaction with retinoblastoma protein. J Biol Chem. 2005; 280(35):30916-23. DOI: 10.1074/jbc.M414482200. View

12.

Etienne-Manneville S, Hall A . Rho GTPases in cell biology. Nature. 2002; 420(6916):629-35. DOI: 10.1038/nature01148. View

13.

Calnan D, Brunet A . The FoxO code. Oncogene. 2008; 27(16):2276-88. DOI: 10.1038/onc.2008.21. View

14.

Walters Z, Villarejo-Balcells B, Olmos D, Buist T, Missiaglia E, Allen R . JARID2 is a direct target of the PAX3-FOXO1 fusion protein and inhibits myogenic differentiation of rhabdomyosarcoma cells. Oncogene. 2013; 33(9):1148-57. PMC: 3982124. DOI: 10.1038/onc.2013.46. View

15.

Wagatsuma A, Shiozuka M, Takayama Y, Hoshino T, Mabuchi K, Matsuda R . Effects of ageing on expression of the muscle-specific E3 ubiquitin ligases and Akt-dependent regulation of Foxo transcription factors in skeletal muscle. Mol Cell Biochem. 2015; 412(1-2):59-72. DOI: 10.1007/s11010-015-2608-7. View

16.

Lin L, Chen K, Abdel Khalek W, Ward 3rd J, Yang H, Chabi B . Regulation of skeletal muscle oxidative capacity and muscle mass by SIRT3. PLoS One. 2014; 9(1):e85636. PMC: 3893254. DOI: 10.1371/journal.pone.0085636. View

17.

Wu H, Naya F, McKinsey T, Mercer B, Shelton J, Chin E . MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. EMBO J. 2000; 19(9):1963-73. PMC: 305686. DOI: 10.1093/emboj/19.9.1963. View

18.

Hirsinger E, Malapert P, Dubrulle J, Delfini M, Duprez D, Henrique D . Notch signalling acts in postmitotic avian myogenic cells to control MyoD activation. Development. 2000; 128(1):107-16. DOI: 10.1242/dev.128.1.107. View

19.

Urbanek P, Klotz L . Posttranscriptional regulation of FOXO expression: microRNAs and beyond. Br J Pharmacol. 2016; 174(12):1514-1532. PMC: 5446586. DOI: 10.1111/bph.13471. View

20.

Zou Z, Xu J, Li L, Han Y . Down-regulation of SENCR promotes smooth muscle cells proliferation and migration in db/db mice through up-regulation of FoxO1 and TRPC6. Biomed Pharmacother. 2015; 74:35-41. DOI: 10.1016/j.biopha.2015.06.009. View