TIS7 Induces Transcriptional Cascade of Methylosome Components Required for Muscle Differentiation

Overview

Journal BMC Biol

Publisher Biomed Central

Specialty Biology

Date 2016 Oct 27

PMID 27782840

Citations 4

Authors

Andrea Lammirato

Katherin Patsch

Fabien Feiereisen

Karl Maly

Charity Nofziger

Markus Paulmichl

Hubert Hackl

Zlatko Trajanoski

Taras Valovka

Lukas A Huber

Ilja Vietor

Affiliations

Soon will be listed here.

Abstract

Background: TPA Induced Sequence 7 acts as a transcriptional co-regulator controlling the expression of genes involved in differentiation of various cell types, including skeletal myoblasts. We and others have shown that TIS7 regulates adult myogenesis through MyoD, one of the essential myogenic regulatory factors.

Results: Here, we present data identifying ICln as the specific, novel protein downstream of TIS7 controlling myogenesis. We show that TIS7/ICln epigenetically regulate myoD expression controlling protein methyl transferase activity. In particular, ICln regulates MyoD expression via its interaction with PRMT5 by an epigenetic modification that utilizes symmetrical di-methylation of histone H3 on arginine 8. We provide multiple evidences that TIS7 directly binds DNA, which is a functional feature necessary for its role in transcriptional regulation.

Conclusion: We present here a molecular insight into TIS7-specific control of MyoD gene expression and thereby skeletal muscle differentiation.

Citing Articles

IFRD2, a target of miR-2400, regulates myogenic differentiation of bovine skeletal muscle satellite cells via decreased phosphorylation of ERK1/2 proteins.

Gong Z, Zhang X, Cui J, Chen W, Huang X, Yang Q J Muscle Res Cell Motil. 2024; 45(4):253-262.

PMID: 38896394 DOI: 10.1007/s10974-024-09677-5.

The negative adipogenesis regulator is transcriptionally regulated by (TIS7) and translationally by its orthologue (SKMc15).

Vietor I, Cikes D, Piironen K, Vasakou T, Heimdorfer D, Gstir R Elife. 2023; 12.

PMID: 37603466 PMC: 10468205. DOI: 10.7554/eLife.88350.

Binding of the protein ICln to α-integrin contributes to the activation of ICl current.

Schedlbauer A, Tamma G, Rodighiero S, Civello D, Tamplenizza M, Ledolter K Sci Rep. 2019; 9(1):12195.

PMID: 31434921 PMC: 6704128. DOI: 10.1038/s41598-019-48496-4.

Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression.

Krapivinsky G, Krapivinsky L, Renthal N, Santa-Cruz A, Manasian Y, Clapham D Proc Natl Acad Sci U S A. 2017; 114(34):E7092-E7100.

PMID: 28784805 PMC: 5576826. DOI: 10.1073/pnas.1708427114.

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