Sweet Bones: The Pathogenesis of Bone Alteration in Diabetes

Overview

Journal J Diabetes Res

Publisher Wiley

Specialty Endocrinology

Date 2016 Oct 26

PMID 27777961

Citations 19

Authors

Mohammed Al-Hariri

Affiliations

Soon will be listed here.

Abstract

Diabetic patients have increased fracture risk. The pathogenesis underlying the status of bone alterations in diabetes mellitus is not completely understood but is multifactorial. The major deficits appear to be related to a deficit in mineralized surface area, a decrement in the rate of mineral apposition, deceased osteoid surface, depressed osteoblast activity, and decreased numbers of osteoclasts due to abnormal insulin signaling pathway. Other prominent features of diabetes mellitus are an increased urinary excretion of calcium and magnesium, accumulation of advanced glycation end products, and oxidative stress leading to sweet bones (altered bone's strength, metabolism, and structure). Every diabetic patient should be assessed for risk factors for fractures and osteoporosis. The pathogenesis of the bone alterations in diabetes mellitus as well as their molecular mechanisms needs further study.

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References

Pooruk P, Kittimanon N, Janthorn P, Bunyaratavej N . The impacts of type 2 diabetes mellitus on bone markers in the elderly Thai women. J Med Assoc Thai. 2009; 92 Suppl5:S45-8. View

Verhaeghe J, Suiker A, Nyomba B, Visser W, Einhorn T, Dequeker J . Bone mineral homeostasis in spontaneously diabetic BB rats. II. Impaired bone turnover and decreased osteocalcin synthesis. Endocrinology. 1989; 124(2):573-82. DOI: 10.1210/endo-124-2-573. View

Paul R, Bailey A . Glycation of collagen: the basis of its central role in the late complications of ageing and diabetes. Int J Biochem Cell Biol. 1996; 28(12):1297-310. DOI: 10.1016/s1357-2725(96)00079-9. View

Anwana A, Garland H . Renal calcium and magnesium handling in experimental diabetes mellitus in the rat. Acta Endocrinol (Copenh). 1990; 122(4):479-86. DOI: 10.1530/acta.0.1220479. View

Holick M . Vitamin D deficiency. N Engl J Med. 2007; 357(3):266-81. DOI: 10.1056/NEJMra070553. View

Curran D, McArdle J, Talwalkar J . Diabetes mellitus and bone disease in cystic fibrosis. Semin Respir Crit Care Med. 2009; 30(5):514-30. DOI: 10.1055/s-0029-1238910. View

Lumachi F, Camozzi V, Tombolan V, Luisetto G . Bone mineral density, osteocalcin, and bone-specific alkaline phosphatase in patients with insulin-dependent diabetes mellitus. Ann N Y Acad Sci. 2009; 1173 Suppl 1:E64-7. DOI: 10.1111/j.1749-6632.2009.04955.x. View

. Lifetime benefits and costs of intensive therapy as practiced in the diabetes control and complications trial. The Diabetes Control and Complications Trial Research Group. JAMA. 1996; 276(17):1409-15. View

Garay-Sevilla M, Nava L, Malacara J, Wrobel K, Perez U . Advanced glycosylation end products (AGEs), insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) in patients with type 2 diabetes mellitus. Diabetes Metab Res Rev. 2000; 16(2):106-13. DOI: 10.1002/(sici)1520-7560(200003/04)16:2<106::aid-dmrr88>3.0.co;2-h. View

10.

Thomas T, Burguera B, Melton 3rd L, Atkinson E, OFallon W, Riggs B . Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women. Bone. 2001; 29(2):114-20. DOI: 10.1016/s8756-3282(01)00487-2. View

11.

Campos Pastor M, Escobar-Jimenez F, Serrano Pardo M . Intensive insulin therapy and bone mineral density in type 1 diabetes mellitus: a prospective study. Osteoporos Int. 2000; 11(5):455-9. DOI: 10.1007/s001980070114. View

12.

Bilik D, McEwen L, Brown M, Pomeroy N, Kim C, Asao K . Thiazolidinediones and fractures: evidence from translating research into action for diabetes. J Clin Endocrinol Metab. 2010; 95(10):4560-5. PMC: 3050101. DOI: 10.1210/jc.2009-2638. View

13.

Gooch H, Hale J, Fujioka H, Balian G, Hurwitz S . Alterations of cartilage and collagen expression during fracture healing in experimental diabetes. Connect Tissue Res. 2000; 41(2):81-91. DOI: 10.3109/03008200009067660. View

14.

Dauphine R, Riggs B, SCHOLZ D . Back pain and vertebral crush fractures: an unemphasized mode of presentation for primary hyperparathyroidism. Ann Intern Med. 1975; 83(3):365-7. DOI: 10.7326/0003-4819-83-3-365. View

15.

Lozano D, de Castro L, Dapia S, Andrade-Zapata I, Manzarbeitia F, Alvarez-Arroyo M . Role of parathyroid hormone-related protein in the decreased osteoblast function in diabetes-related osteopenia. Endocrinology. 2009; 150(5):2027-35. DOI: 10.1210/en.2008-1108. View

16.

Selby P . Osteopenia and diabetes. Diabet Med. 1988; 5(5):423-8. DOI: 10.1111/j.1464-5491.1988.tb01021.x. View

17.

Wallace C, Reiber G, LeMaster J, Smith D, Sullivan K, Hayes S . Incidence of falls, risk factors for falls, and fall-related fractures in individuals with diabetes and a prior foot ulcer. Diabetes Care. 2002; 25(11):1983-6. DOI: 10.2337/diacare.25.11.1983. View

18.

Krakauer J, McKenna M, Buderer N, Rao D, WHITEHOUSE F, Parfitt A . Bone loss and bone turnover in diabetes. Diabetes. 1995; 44(7):775-82. DOI: 10.2337/diab.44.7.775. View

19.

Vestergaard P, Rejnmark L, Mosekilde L . Diabetes and its complications and their relationship with risk of fractures in type 1 and 2 diabetes. Calcif Tissue Int. 2008; 84(1):45-55. DOI: 10.1007/s00223-008-9195-5. View

20.

Piepkorn B, Kann P, Forst T, Andreas J, Pfutzner A, Beyer J . Bone mineral density and bone metabolism in diabetes mellitus. Horm Metab Res. 1998; 29(11):584-91. DOI: 10.1055/s-2007-979106. View