Epidemiology of American Tegumentary Leishmaniasis and Infection in the Northwestern Argentina

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2016 Oct 26

PMID 27777950

Citations 6

Authors

Carlos L Hoyos

Silvana P Cajal

Marisa Juarez

Jorge D Marco

Anahi M Alberti DAmato

Melina Cayo

Irma Torrejon

Ruben O Cimino

Patricio Diosque

Alejandro J Krolewiecki

Julio R Nasser

Jose F Gil

Affiliations

Soon will be listed here.

Abstract

. Endemic areas of tegumentary leishmaniasis (TL) in Salta, Argentina, present some overlap zones with the geographical distribution of Chagas disease, with mixed infection cases being often detected. . The purpose of this study was to determine the magnitude of sp. infection and potential associated risk factors, the serologic prevalence of and the presence of - sp. mixed infection in a region of the northwest of Argentina. . Cross-sectional studies were conducted to detect TL prevalence and seroprevalence. A case-control study was conducted to examine leishmaniasis risk factors. . Prevalence of TL was 0.17%, seroprevalence of infection was 9.73%, and mixed infection proportion-within the leishmaniasic patients group-was 16.67%. The risk factors associated with TL transmission were sex, age, exposure to bites at work, staying outdoors more than 10 hours/day, bathing in the river, and living with people who had lesions or were infected during the study. . The endemic pattern of TL seems to involve exposure of patients to vectors in wild as well as peridomestic environment. Cases of infection are apparently due to migration. Therefore, a careful epidemiological surveillance is necessary due to the contraindication of antimonial administration to chagasic patients.

Citing Articles

Understanding Sex-biases in Kinetoplastid Infections: Leishmaniasis and Trypanosomiasis.

Battistoni O, Huston R, Verma C, Pacheco-Fernandez T, Abul-Khoudoud S, Campbell A Expert Rev Mol Med. 2025; 27:e7.

PMID: 39781597 PMC: 11803520. DOI: 10.1017/erm.2024.41.

Chagas Disease and Leishmaniasis, Sympatric Zoonoses Present in Human from Rural Communities of Venezuela.

Ferrer E, Aguilar C, Viettri M, Torrellas A, Lares M, Diaz M Acta Parasitol. 2024; 69(1):616-627.

PMID: 38294711 DOI: 10.1007/s11686-023-00786-8.

Big is not better: Comparing two alpha-Gal-bearing glycotopes in neoglycoproteins as biomarkers for Leishmania (Viannia) braziliensis infection.

Montoya A, Gil E, Vinales I, Estevao I, Taboada P, Torrico M Carbohydr Res. 2024; 536:109015.

PMID: 38198982 PMC: 11366264. DOI: 10.1016/j.carres.2023.109015.

Leishmania kinetoplast DNA contributes to parasite burden in infected macrophages: Critical role of the cGAS-STING-TBK1 signaling pathway in macrophage parasitemia.

Yilmaz I, Dunuroglu E, Ayanoglu I, Ipekoglu E, Yildirim M, Girginkardesler N Front Immunol. 2022; 13:1007070.

PMID: 36405710 PMC: 9667060. DOI: 10.3389/fimmu.2022.1007070.

Leishmaniasis en Bolivia. Comprehensive review and current status in Tarija, in the border with Argentina.

Mollinedo J, Mollinedo Z, Magne M, Gironda W, Salomon O Biomedica. 2020; 40(Supl. 1):45-61.

PMID: 32463608 PMC: 7449108. DOI: 10.7705/biomedica.4990.

References

Sosa-Estani S, Segura E, Gomez A, Salomon O, Peralta M, Coutada V . [Cutaneous leishmaniasis in Northern Argentina: identification of risk factors in a case-cohort study of three municipalities in Salta]. Rev Soc Bras Med Trop. 2002; 34(6):511-7. DOI: 10.1590/s0037-86822001000600003. View

Gil J, Nasser J, Cajal S, Juarez M, Acosta N, Cimino R . Urban transmission of American cutaneous leishmaniasis in Argentina: spatial analysis study. Am J Trop Med Hyg. 2010; 82(3):433-40. PMC: 2829905. DOI: 10.4269/ajtmh.2010.09-0113. View

Dias J . Human chagas disease and migration in the context of globalization: some particular aspects. J Trop Med. 2013; 2013:789758. PMC: 3625591. DOI: 10.1155/2013/789758. View

Malik L, Singh G, Amsterdam E . The Epidemiology, Clinical Manifestations, and Management of Chagas Heart Disease. Clin Cardiol. 2015; 38(9):565-9. PMC: 6490782. DOI: 10.1002/clc.22421. View

Krolewiecki A, Gil J, Quipildor M, Cajal S, Pravia C, Juarez M . Restricted outbreak of American tegumentary leishmaniasis with high microfocal transmission. Am J Trop Med Hyg. 2013; 88(3):578-82. PMC: 3592545. DOI: 10.4269/ajtmh.12-0475. View

Marco J, Barroso P, Mimori T, Locatelli F, Tomatani A, Mora M . Polymorphism-specific PCR enhances the diagnostic performance of American tegumentary leishmaniasis and allows the rapid identification of Leishmania species from Argentina. BMC Infect Dis. 2012; 12:191. PMC: 3449195. DOI: 10.1186/1471-2334-12-191. View

Oliveira L, Schubach A, Martins M, Passos S, Oliveira R, Marzochi M . Systematic review of the adverse effects of cutaneous leishmaniasis treatment in the New World. Acta Trop. 2011; 118(2):87-96. DOI: 10.1016/j.actatropica.2011.02.007. View

Britto C, Cardoso M, Vanni C, Xavier S, Oelemann W, Santoro A . Polymerase chain reaction detection of Trypanosoma cruzi in human blood samples as a tool for diagnosis and treatment evaluation. Parasitology. 1995; 110 ( Pt 3):241-7. DOI: 10.1017/s0031182000080823. View

Caballero Z, Sousa O, Marques W, Saez-Alquezar A, Umezawa E . Evaluation of serological tests to identify Trypanosoma cruzi infection in humans and determine cross-reactivity with Trypanosoma rangeli and Leishmania spp. Clin Vaccine Immunol. 2007; 14(8):1045-9. PMC: 2044488. DOI: 10.1128/CVI.00127-07. View

10.

Dominguez-Almendros S, Benitez-Parejo N, Gonzalez-Ramirez A . Logistic regression models. Allergol Immunopathol (Madr). 2011; 39(5):295-305. DOI: 10.1016/j.aller.2011.05.002. View

11.

Negrette O, Mora M, Basombrio M . High prevalence of congenital Trypanosoma cruzi infection and family clustering in Salta, Argentina. Pediatrics. 2005; 115(6):e668-72. DOI: 10.1542/peds.2004-1732. View

12.

Sosa-Estani S, Segura E, Salomon O, Gomez A, Peralta M, Coutada V . Tegumentary leishmaniasis in Northern Argentina: distribution of infection and disease, in three municipalities of Salta, 1990-1992. Rev Soc Bras Med Trop. 2001; 33(6):573-82. DOI: 10.1590/s0037-86822000000600009. View

13.

Salomon O, Orellano P, Quintana M, Perez S, Sosa Estani S, Acardi S . [Transmission of tegumentary leishmaniasis in Argentina]. Medicina (B Aires). 2006; 66(3):211-9. View

14.

Vega Benedetti A, Cimino R, Cajal P, Juarez M, Villalpando C, Gil J . Performance of different Trypanosoma cruzi antigens in the diagnosis of Chagas disease in patients with American cutaneous leishmaniasis from a co-endemic region in Argentina. Trop Med Int Health. 2013; 18(9):1103-1109. DOI: 10.1111/tmi.12144. View

15.

Chiaramonte M, Frank F, Furer G, Taranto N, Margni R, Malchiodi E . Polymerase chain reaction reveals Trypanosoma cruzi infection suspected by serology in cutaneous and mucocutaneous leishmaniasis patients. Acta Trop. 1999; 72(3):295-308. DOI: 10.1016/s0001-706x(99)00005-4. View

16.

Frank F, Fernandez M, Taranto N, Cajal S, Margni R, Castro E . Characterization of human infection by Leishmania spp. in the Northwest of Argentina: immune response, double infection with Trypanosoma cruzi and species of Leishmania involved. Parasitology. 2003; 126(Pt 1):31-9. DOI: 10.1017/s0031182002002585. View

17.

Salomon O, Wilson M, Munstermann L, Travi B . Spatial and temporal patterns of phlebotomine sand flies (Diptera: Psychodidae) in a cutaneous leishmaniasis focus in northern Argentina. J Med Entomol. 2004; 41(1):33-9. DOI: 10.1603/0022-2585-41.1.33. View

18.

Gil J, Cimino R, Lopez Quiroga I, Cajal S, Acosta N, Juarez M . [Reactivity of GST-SAPA antigen of Trypanosoma cruzi against sera from patients with Chagas disease and leishmaniasis]. Medicina (B Aires). 2011; 71(2):113-9. View

19.

Quintana M, Salomon O, De Grosso M . Distribution of phlebotomine sand flies (Diptera: Psychodidae) in a primary forest-crop interface, Salta, Argentina. J Med Entomol. 2010; 47(6):1003-10. DOI: 10.1603/me09072. View

20.

Gil J, Hoyos C, Cimino R, Krolewiecki A, Lopez Quiroga I, Cajal S . [Role of three ELISA tests using promastigote homogenates of Leishmania braziliensis, L. amazonensis and L. guyanensis in the diagnosis of tegumentary leishmaniasis]. Medicina (B Aires). 2011; 71(5):420-8. View