Therapeutic Inhibition of Prolyl Hydroxylase Domain-containing Enzymes in Surgery: Putative Applications and Challenges

Overview

Journal Hypoxia (Auckl)

Publisher Dove Medical Press

Date 2015 Jan 30

PMID 27774478

Citations 11

Authors

Jonathan Michael Harnoss

Moritz Johannes Strowitzki

Praveen Radhakrishnan

Lisa Katharina Platzer

Julian Camill Harnoss

Thomas Hank

Jun Cai

Alexis Ulrich

Martin Schneider

Affiliations

Soon will be listed here.

Abstract

Oxygen is essential for metazoans to generate energy. Upon oxygen deprivation adaptive and protective pathways are induced, mediated by hypoxia-inducible factors (HIFs) and prolyl hydroxylase domain-containing enzymes (PHDs). Both play a pivotal role in various conditions associated with prolonged ischemia and inflammation, and are promising targets for therapeutic intervention. This review focuses on aspects of therapeutic PHD modulation in surgically relevant disease conditions such as hepatic and intestinal disorders, wound healing, innate immune responses, and tumorigenesis, and discusses the therapeutic potential and challenges of PHD inhibition in surgical patients.

Citing Articles

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Erber L, Luo A, Chen Y Mol Cell Proteomics. 2019; 18(9):1772-1781.

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Fan Q, Mao H, Xie L, Pi X Am J Pathol. 2018; 189(1):200-213.

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