A Novel Astrovirus-Like RNA Virus Detected in Human Stool

Overview

Journal Virus Evol

Publisher Oxford University Press

Date 2016 Oct 25

PMID 27774298

Citations 13

Authors

Bas B Oude Munnink

Matthew Cotten

Marta Canuti

Martin Deijs

Maarten F Jebbink

Formijn J van Hemert

My V T Phan

Margreet Bakker

Seyed Mohammad Jazaeri Farsani

Paul Kellam

Lia van der Hoek

Affiliations

Soon will be listed here.

Abstract

Several novel clades of astroviruses have recently been identified in human faecal samples. Here, we describe a novel astrovirus-like RNA virus detected in human stools, which we have tentatively named bastrovirus. The genome of this novel virus consists of 6,300 nucleotides organized in three open reading frames. Several sequence divergent strains were detected sharing 67-93 per cent nucleotide identity. Bastrovirus encodes a putative structural protein that is homologous to the capsid protein found in members of the family (45% amino acid identity). The virus also encodes a putative non-structural protein that is genetically distant from astroviruses but shares some homology to the non-structural protein encoded by members of the family (28% amino acid identity). This novel bastrovirus is present in 8.7 per cent (35/400) of faecal samples collected from 300 HIV-1-positive and 100 HIV-1-negative individuals suggesting common occurrence of the virus. However, whether the source of the virus is infected human cells or other, for example, dietary, remains to be determined.

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