SR-BI: Linking Cholesterol and Lipoprotein Metabolism with Breast and Prostate Cancer

Overview

Journal Front Pharmacol

Date 2016 Oct 25

PMID 27774064

Citations 39

Authors

Jorge L Gutierrez-Pajares

Celine Ben Hassen

Stephan Chevalier

Philippe G Frank

Affiliations

Soon will be listed here.

Abstract

Studies have demonstrated the significant role of cholesterol and lipoprotein metabolism in the progression of cancer. The gene encodes the scavenger receptor class B type I (SR-BI), which is an 82-kDa glycoprotein with two transmembrane domains separated by a large extracellular loop. SR-BI plays an important role in the regulation of cholesterol exchange between cells and high-density lipoproteins. Accordingly, hepatic SR-BI has been shown to play an essential role in the regulation of the reverse cholesterol transport pathway, which promotes the removal and excretion of excess body cholesterol. In the context of atherosclerosis, SR-BI has been implicated in the regulation of intracellular signaling, lipid accumulation, foam cell formation, and cellular apoptosis. Furthermore, since lipid metabolism is a relevant target for cancer treatment, recent studies have focused on examining the role of SR-BI in this pathology. While signaling pathways have initially been explored in non-tumoral cells, studies with cancer cells have now demonstrated SR-BI's function in tumor progression. In this review, we will discuss the role of SR-BI during tumor development and malignant progression. In addition, we will provide insights into the transcriptional and post-transcriptional regulation of the gene. Overall, studying the role of SR-BI in tumor development and progression should allow us to gain useful information for the development of new therapeutic strategies.

Citing Articles

Lipid Profile, PCSK9, ANGPTL3 and Lipoprotein (a) Levels in Men Diagnosed With Localized High-Grade Prostate Cancer and Men At-Risk of Prostate Cancer.

Bergeron A, Wong-Chong E, Joncas F, Castonguay C, Calon F, Seidah N Cancer Med. 2025; 14(3):e70587.

PMID: 39888285 PMC: 11783234. DOI: 10.1002/cam4.70587.

Encapsulation and Delivery of the Kinase Inhibitor PIK-75 by Organic Core High-Density Lipoprotein-Like Nanoparticles Targeting Scavenger Receptor Class B Type 1.

Rink J, Lin A, Calvert A, Kwon D, Moxley A, Henrich S ACS Appl Mater Interfaces. 2024; 17(1):363-373.

PMID: 39688216 PMC: 11784712. DOI: 10.1021/acsami.4c15472.

Oxidized Low-Density Lipoprotein and Its Role in Immunometabolism.

Mosalmanzadeh N, Pence B Int J Mol Sci. 2024; 25(21).

PMID: 39518939 PMC: 11545486. DOI: 10.3390/ijms252111386.

Why make it if you can take it: review on extracellular cholesterol uptake and its importance in breast and ovarian cancers.

Lauridsen A, Skorda A, Winther N, Bay M, Kallunki T J Exp Clin Cancer Res. 2024; 43(1):254.

PMID: 39243069 PMC: 11378638. DOI: 10.1186/s13046-024-03172-y.

A population-based cohort study of longitudinal change of high-density lipoprotein cholesterol impact on gastrointestinal cancer risk.

Nam S, Jo J, Cho C Nat Commun. 2024; 15(1):2923.

PMID: 38575589 PMC: 10994902. DOI: 10.1038/s41467-024-47193-9.

References

Arenas M, Lobo M, Caso E, Huerta L, Paniagua R, Martin-Hidalgo M . Normal and pathological human testes express hormone-sensitive lipase and the lipid receptors CLA-1/SR-BI and CD36. Hum Pathol. 2004; 35(1):34-42. DOI: 10.1016/j.humpath.2003.08.015. View

Li S, Ma Y, Hou X, Liu Y, Li K, Xu S . MiR-185 acts as a tumor suppressor by targeting AKT1 in non-small cell lung cancer cells. Int J Clin Exp Pathol. 2015; 8(9):11854-62. PMC: 4637756. View

Webb N, de Villiers W, Connell P, de Beer F, van der Westhuyzen D . Alternative forms of the scavenger receptor BI (SR-BI). J Lipid Res. 1997; 38(7):1490-5. View

Harder C, Meng A, Rippstein P, McBride H, McPherson R . SR-BI undergoes cholesterol-stimulated transcytosis to the bile canaliculus in polarized WIF-B cells. J Biol Chem. 2006; 282(2):1445-55. DOI: 10.1074/jbc.M604627200. View

Pussinen P, Karten B, Wintersperger A, Reicher H, McLean M, Malle E . The human breast carcinoma cell line HBL-100 acquires exogenous cholesterol from high-density lipoprotein via CLA-1 (CD-36 and LIMPII analogous 1)-mediated selective cholesteryl ester uptake. Biochem J. 2000; 349(Pt 2):559-66. PMC: 1221179. DOI: 10.1042/0264-6021:3490559. View

Gantman A, Fuhrman B, Aviram M, Hayek T . High glucose stimulates macrophage SR-BI expression and induces a switch in its activity from cholesterol efflux to cholesterol influx. Biochem Biophys Res Commun. 2009; 391(1):523-8. DOI: 10.1016/j.bbrc.2009.11.091. View

Danilo C, Gutierrez-Pajares J, Mainieri M, Mercier I, Lisanti M, Frank P . Scavenger receptor class B type I regulates cellular cholesterol metabolism and cell signaling associated with breast cancer development. Breast Cancer Res. 2013; 15(5):R87. PMC: 3978612. DOI: 10.1186/bcr3483. View

Zhou H, Tan K, Shiu S, Wong Y . Cellular cholesterol efflux to serum is impaired in diabetic nephropathy. Diabetes Metab Res Rev. 2008; 24(8):617-23. DOI: 10.1002/dmrr.895. View

Webb N, Connell P, Graf G, Smart E, de Villiers W, de Beer F . SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high density lipoprotein and cells. J Biol Chem. 1998; 273(24):15241-8. DOI: 10.1074/jbc.273.24.15241. View

10.

Kuzu O, Noory M, Robertson G . The Role of Cholesterol in Cancer. Cancer Res. 2016; 76(8):2063-70. PMC: 5813477. DOI: 10.1158/0008-5472.CAN-15-2613. View

11.

Twiddy A, Cox M, Wasan K . Knockdown of scavenger receptor class B type I reduces prostate specific antigen secretion and viability of prostate cancer cells. Prostate. 2011; 72(9):955-65. DOI: 10.1002/pros.21499. View

12.

Silvente-Poirot S, Poirot M . Cholesterol metabolism and cancer: the good, the bad and the ugly. Curr Opin Pharmacol. 2012; 12(6):673-6. DOI: 10.1016/j.coph.2012.10.004. View

13.

Kimura T, Tomura H, Sato K, Ito M, Matsuoka I, Im D . Mechanism and role of high density lipoprotein-induced activation of AMP-activated protein kinase in endothelial cells. J Biol Chem. 2009; 285(7):4387-97. PMC: 2836043. DOI: 10.1074/jbc.M109.043869. View

14.

Guo X, Wu Y, Hartley R . MicroRNA-125a represses cell growth by targeting HuR in breast cancer. RNA Biol. 2009; 6(5):575-83. PMC: 3645467. DOI: 10.4161/rna.6.5.10079. View

15.

Tang H, Liu P, Yang L, Xie X, Ye F, Wu M . miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer. Mol Cancer Ther. 2014; 13(12):3185-97. DOI: 10.1158/1535-7163.MCT-14-0243. View

16.

Llaverias G, Danilo C, Wang Y, Witkiewicz A, Daumer K, Lisanti M . A Western-type diet accelerates tumor progression in an autochthonous mouse model of prostate cancer. Am J Pathol. 2010; 177(6):3180-91. PMC: 2993263. DOI: 10.2353/ajpath.2010.100568. View

17.

Krycer J, Brown A . Cholesterol accumulation in prostate cancer: a classic observation from a modern perspective. Biochim Biophys Acta. 2013; 1835(2):219-29. DOI: 10.1016/j.bbcan.2013.01.002. View

18.

Nieland T, Penman M, Dori L, Krieger M, Kirchhausen T . Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptor SR-BI. Proc Natl Acad Sci U S A. 2002; 99(24):15422-7. PMC: 137732. DOI: 10.1073/pnas.222421399. View

19.

Norata G, Ongari M, Uboldi P, Pellegatta F, Catapano A . Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells. Int J Mol Med. 2005; 16(4):717-22. View

20.

Rhainds D, Bourgeois P, Bourret G, Huard K, Falstrault L, Brissette L . Localization and regulation of SR-BI in membrane rafts of HepG2 cells. J Cell Sci. 2004; 117(Pt 15):3095-105. DOI: 10.1242/jcs.01182. View