Genetic and Serological Heterogeneity of the Supertypic HLA-B Locus Specificities Bw4 and Bw6

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 1989 Jan 1

PMID 2777338

Citations 35

Authors

C A Muller

V Gekeler

I Steiert

E Weiss

H Schmidt

Affiliations

Soon will be listed here.

Abstract

Gene cloning and sequencing of the HLA-B locus split antigens B38 (B16.1) and B39 (B16.2) allowed localization of their subtypic as well as their public specificities HLA-Bw4 or -Bw6 to the alpha-helical region of the alpha 1 domain flanked by the amino acid positions 74-83. Comparison of their amino acid sequences with those of other HLA-B-locus alleles established HLA-Bw6 to be distinguished by Ser at residue 77 and Asn at residue 80. In contrast, HLA-Bw4 is characterized by at least seven different patterns of amino acid exchanges at positions 77 and 80-83. Reactivity patterns of Bw4- or Bw6-specific monoclonal antibodies reveal two alloantigenic epitopes contributing to the HLA-Bw4 or -Bw6 specificity residing next to the region of highest diversity of the alpha 1 domain.

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