» Articles » PMID: 27770215

Preferences for Long-Acting Pre-exposure Prophylaxis (PrEP), Daily Oral PrEP, or Condoms for HIV Prevention Among U.S. Men Who Have Sex with Men

Overview
Journal AIDS Behav
Date 2016 Oct 23
PMID 27770215
Citations 83
Authors
Affiliations
Soon will be listed here.
Abstract

HIV prevention method preferences were evaluated among 512 U.S. men who have sex with men (MSM; median age: 22 years). Approximately 90 % consistently preferred one option across pairwise comparisons of condoms, daily oral pre-exposure prophylaxis (PrEP), and long-acting PrEP delivered via either an injectable or one of two types of PrEP implants differing in visibility. Condoms were most frequently preferred (33.8 %), followed by non-visible implants (21.5 %), and oral PrEP (17.0 %); HIV risk was reported by more choosing implants. In a follow-up question comparing the four PrEP options only, daily oral pills and non-visible implants were most frequently preferred (35.5 and 34.3 %, respectively), followed by injections (25.2 %) and visible implants (4.3 %). An inductive, open-coding approach determined that convenience, duration of protection, and privacy were the most commonly cited reasons for a PrEP method choice, and associated with self-report of HIV risk. Tailoring PrEP product development to privacy and other concerns important to those at highest HIV risk may improve HIV prevention.

Citing Articles

Achieving the state of Georgia 25% HIV incidence reduction target among men who have sex with men in Atlanta through expanded use of multimodal pre-exposure prophylaxis: A mathematical model.

Fraysse J, Anderson S, Smith J, Matthews D, Sarkar S, de Aragao F PLoS One. 2025; 20(1):e0312369.

PMID: 39787101 PMC: 11717278. DOI: 10.1371/journal.pone.0312369.


Lower PrEP Retention among Young and Black Clients Accessing PrEP at a Cluster of Safety Net Clinics for Gay and Bisexual Men.

Agarwal H, Erwin M, Lyles S, Esposito M, Ahsan Z J Int Assoc Provid AIDS Care. 2024; 23:23259582241275857.

PMID: 39219500 PMC: 11375660. DOI: 10.1177/23259582241275857.


Modeling of HIV-1 prophylactic efficacy and toxicity with islatravir shows non-superiority for oral dosing, but promise as a subcutaneous implant.

Kim H, Zhang L, Hendrix C, Haberer J, von Kleist M CPT Pharmacometrics Syst Pharmacol. 2024; 13(10):1693-1706.

PMID: 39164932 PMC: 11494919. DOI: 10.1002/psp4.13212.


Behind Prep Decisions: Understanding User Patterns and Discontinuation Factors in Real-World.

Braz Junior R, Cesar G, Amianti C, Bandeira L, Da Silva A, Motta-Castro A AIDS Behav. 2024; 28(9):2979-2989.

PMID: 38825651 DOI: 10.1007/s10461-024-04383-2.


Perspectives on Injectable HIV Pre-Exposure Prophylaxis: A Qualitative Study of Health Care Providers in the United States.

Bleasdale J, McCole M, Cole K, Hequembourg A, Morse G, Przybyla S AIDS Patient Care STDS. 2024; 38(4):177-184.

PMID: 38656214 PMC: 11236283. DOI: 10.1089/apc.2024.0001.


References
1.
Margolis D, Boffito M . Long-acting antiviral agents for HIV treatment. Curr Opin HIV AIDS. 2015; 10(4):246-52. PMC: 5638428. DOI: 10.1097/COH.0000000000000169. View

2.
Voetsch A, Heffelfinger J, Begley E, Jafa-Bhushan K, Sullivan P . Knowledge and use of preexposure and postexposure prophylaxis among attendees of Minority Gay Pride events, 2005 through 2006. J Acquir Immune Defic Syndr. 2007; 46(3):378-80. DOI: 10.1097/QAI.0b013e3181576874. View

3.
Boffito M, Jackson A, Owen A, Becker S . New approaches to antiretroviral drug delivery: challenges and opportunities associated with the use of long-acting injectable agents. Drugs. 2013; 74(1):7-13. DOI: 10.1007/s40265-013-0163-7. View

4.
Golub S, Kowalczyk W, Weinberger C, Parsons J . Preexposure prophylaxis and predicted condom use among high-risk men who have sex with men. J Acquir Immune Defic Syndr. 2010; 54(5):548-55. PMC: 2908204. DOI: 10.1097/QAI.0b013e3181e19a54. View

5.
McCormack S, Dunn D, Desai M, Dolling D, Gafos M, Gilson R . Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial. Lancet. 2015; 387(10013):53-60. PMC: 4700047. DOI: 10.1016/S0140-6736(15)00056-2. View