Development of the Cardiac Pacemaker

Overview

Journal Cell Mol Life Sci

Publisher Springer

Specialty Biology

Date 2016 Oct 23

PMID 27770149

Citations 15

Authors

Xingqun Liang

Sylvia M Evans

Yunfu Sun

Affiliations

Soon will be listed here.

Abstract

The sinoatrial node (SAN) is the dominant pacemaker of the heart. Abnormalities in SAN formation and function can cause sinus arrhythmia, including sick sinus syndrome and sudden death. A better understanding of genes and signaling pathways that regulate SAN development and function is essential to develop more effective treatment to sinus arrhythmia, including biological pacemakers. In this review, we briefly summarize the key processes of SAN morphogenesis during development, and focus on the transcriptional network that drives SAN development.

Citing Articles

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A new paradigm for generating high-quality cardiac pacemaker cells from mouse pluripotent stem cells.

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Conversion of Unmodified Stem Cells to Pacemaker Cells by Overexpression of Key Developmental Genes.

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High cardiomyocyte diversity in human early prenatal heart development.

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