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Development of the Cardiac Pacemaker

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Publisher Springer
Specialty Biology
Date 2016 Oct 23
PMID 27770149
Citations 15
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Abstract

The sinoatrial node (SAN) is the dominant pacemaker of the heart. Abnormalities in SAN formation and function can cause sinus arrhythmia, including sick sinus syndrome and sudden death. A better understanding of genes and signaling pathways that regulate SAN development and function is essential to develop more effective treatment to sinus arrhythmia, including biological pacemakers. In this review, we briefly summarize the key processes of SAN morphogenesis during development, and focus on the transcriptional network that drives SAN development.

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References
1.
Hoogaars W, Tessari A, Moorman A, de Boer P, Hagoort J, Soufan A . The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart. Cardiovasc Res. 2004; 62(3):489-99. DOI: 10.1016/j.cardiores.2004.01.030. View

2.
Dobrzynski H, Boyett M, Anderson R . New insights into pacemaker activity: promoting understanding of sick sinus syndrome. Circulation. 2007; 115(14):1921-32. DOI: 10.1161/CIRCULATIONAHA.106.616011. View

3.
VAN MIEROP L . Location of pacemaker in chick embryo heart at the time of initiation of heartbeat. Am J Physiol. 1967; 212(2):407-15. DOI: 10.1152/ajplegacy.1967.212.2.407. View

4.
Csepe T, Kalyanasundaram A, Hansen B, Zhao J, Fedorov V . Fibrosis: a structural modulator of sinoatrial node physiology and dysfunction. Front Physiol. 2015; 6:37. PMC: 4325882. DOI: 10.3389/fphys.2015.00037. View

5.
Bakker M, Boink G, Boukens B, Verkerk A, van den Boogaard M, den Haan A . T-box transcription factor TBX3 reprogrammes mature cardiac myocytes into pacemaker-like cells. Cardiovasc Res. 2012; 94(3):439-49. DOI: 10.1093/cvr/cvs120. View