Cardiomyopathy-related Mutation (A30V) in Mouse Cardiac Troponin T Divergently Alters the Magnitude of Stretch Activation in α- and β-myosin Heavy Chain Fibers

Overview

Journal Am J Physiol Heart Circ Physiol

Publisher American Physiological Society

Specialties Cardiology & Vascular Diseases
Physiology

Date 2016 Oct 23

PMID 27769999

Citations 2

Authors

Alexis V Mickelson

Sampath K Gollapudi

Murali Chandra

Affiliations

Soon will be listed here.

Abstract

New & Noteworthy: The differential impact of α- and β-myosin heavy chain (MHC) on contractile dynamics causes a mutant cardiac troponin T (TnT) to differently modulate cardiac contractile function. TnT attenuated Ca-activated maximal tension and length-mediated cross-bridge recruitment against α-MHC but augmented these parameters against β-MHC, suggesting divergent contractile phenotypes.

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