Identification of the Ferroxidase Centre in Ferritin

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 1989 Aug 28

PMID 2776883

Citations 80

Authors

D M Lawson

A Treffry

P J Artymiuk

P M Harrison

S J Yewdall

A Luzzago

G Cesareni

S Levi

P Arosio

Affiliations

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Abstract

Ferroxidase activity in human H-chain ferritin has been studied with the aid of site-directed mutagenesis. A site discovered by X-ray crystallography has now been identified as the ferroxidase centre. This centre is present only in H-chains and is located within the four-helix bundle of the chain fold.

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