Article: Morphological integration in the cranium during anuran metamorphosis

We examined the role of thyroid hormone in mediating morphological integration between cranial cartilage and bone during anuran metamorphosis. Exogenous T3 applied to premetamorphic tadpoles (Bombina orientalis) via intracranial implants of plastic micropellets precociously induced typical metamorphic changes in both tissues, but also dissociated the relative timing of developmental events between them. Morphological integration between the two primary cranial tissues is achieved in part by each tissue responding independently to endocrine factors and does not reflect a tight developmental coupling between them.

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References

1.

Hanken J, Hall B . Skull development during anuran metamorphosis: I. Early development of the first three bones to form--the exoccipital, the parasphenoid, and the frontoparietal. J Morphol. 1988; 195(3):247-56. DOI: 10.1002/jmor.1051950303. View

2.

Moss M . A theoretical analysis of the functional matrix. Acta Biotheor. 1968; 18(1):195-202. DOI: 10.1007/BF01556727. View

3.

Silberstein G, DANIEL C . Elvax 40P implants: sustained, local release of bioactive molecules influencing mammary ductal development. Dev Biol. 1982; 93(1):272-8. DOI: 10.1016/0012-1606(82)90259-7. View

4.

Raisz L, Canalis E, Dietrich J, Kream B, Gworek S . Hormonal regulation of bone formation. Recent Prog Horm Res. 1978; 34:335-56. DOI: 10.1016/b978-0-12-571134-0.50013-2. View

5.

Dingerkus G, Uhler L . Enzyme clearing of alcian blue stained whole small vertebrates for demonstration of cartilage. Stain Technol. 1977; 52(4):229-32. DOI: 10.3109/10520297709116780. View

6.

Hanken J, Hall B . Skull development during anuran metamorphosis. II. Role of thyroid hormone in osteogenesis. Anat Embryol (Berl). 1988; 178(3):219-27. DOI: 10.1007/BF00318225. View

7.

Dhanarajan Z, Atkinson B . Thyroid-hormone-induced differentiation and development of anuran tadpole hind limbs: detection and quantitation of M-line protein and alpha-actinin synthesis. Dev Biol. 1981; 82(2):317-28. DOI: 10.1016/0012-1606(81)90455-3. View

8.

Burch W, Van Wyk J . Triiodothyronine stimulates cartilage growth and maturation by different mechanisms. Am J Physiol. 1987; 252(2 Pt 1):E176-82. DOI: 10.1152/ajpendo.1987.252.2.E176. View

9.

Hanken J, Summers C . Skull development during anuran metamorphosis: III. Role of thyroid hormone in chondrogenesis. J Exp Zool. 1988; 246(2):156-70. DOI: 10.1002/jez.1402460208. View

10.

Cheverud J . PHENOTYPIC, GENETIC, AND ENVIRONMENTAL MORPHOLOGICAL INTEGRATION IN THE CRANIUM. Evolution. 2017; 36(3):499-516. DOI: 10.1111/j.1558-5646.1982.tb05070.x. View

11.

KEMP N, Hoyt J . Ossification of the femur in thyroxine-treated tadpoles of Rana pipiens. Dev Biol. 1969; 20(5):387-410. DOI: 10.1016/0012-1606(69)90022-0. View

12.

Roth G, Wake D . Trends in the functional morphology and sensorimotor control of feeding behavior in salamanders: an example of the role of internal dynamics in evolution. Acta Biotheor. 1985; 34(2-4):175-91. DOI: 10.1007/BF00046783. View

Morphological Integration in the Cranium During Anuran Metamorphosis