Immunohistochemical Expression of Vascular Endothelial Growth Factor in Orofacial Lesions - A Review
Overview
Affiliations
Angiogenesis is considered to be an important biological process in disease progression and tumorigenesis. Among the various factors associated with angiogenesis, vascular endothelial growth factor (VEGF) is a leading candidate. VEGF induces the proliferation, differentiation, and migration of vascular endothelial cells, increases capillary permeability, and enhances endothelial cell survival by preventing apoptosis. This article reviews and highlights the role of VEGF in health, and various oral diseases.
Ma Z, Wu X, Cao L, Jiao C, Ma D, Zhao Y Front Immunol. 2025; 16:1529883.
PMID: 39931068 PMC: 11808821. DOI: 10.3389/fimmu.2025.1529883.
Vascular Endothelial Growth Factor: A Translational View in Oral Non-Communicable Diseases.
Niklander S, Bordagaray M, Fernandez A, Hernandez M Biomolecules. 2021; 11(1).
PMID: 33445558 PMC: 7826734. DOI: 10.3390/biom11010085.
Correlation of VEGF and MMP-2 levels in oral lichen planus: An in vivo immunohistochemical study.
Hazzaa H, El Shiekh M, Abdelgawad N, Gouda O, Kamal N J Oral Biol Craniofac Res. 2020; 10(4):747-752.
PMID: 33101894 PMC: 7578756. DOI: 10.1016/j.jobcr.2020.10.009.
Shamloo N, Taghavi N, Yazdani F, Azimian P, Ahmadi S Dent Res J (Isfahan). 2020; 17(2):100-106.
PMID: 32435431 PMC: 7224257.