The Role of Platelets and Megakaryocytes in Bone Metastasis

Overview

Journal J Bone Oncol

Publisher Elsevier

Date 2016 Oct 21

PMID 27761368

Citations 13

Authors

Raphael Leblanc

Olivier Peyruchaud

Affiliations

Soon will be listed here.

Abstract

Blood platelets have been known for more than a century as important partners for successful metastatic dissemination of solid tumors. Cancer cell-induced platelet activation is a key event responsible for prometastatic activity of platelets. Blocking platelet aggregation inhibits the progression of skeletal metastases through mechanisms that are not fully understood. The establishment and progression of bone metastases are strongly influenced by the bone remodeling process. Growth factors and cytokines released upon platelet activation may contribute to both skeletal tumor growth and osteolytic lesions. Megakaryocytes are platelet precursors located in the bone marrow that control bone mass through direct stimulation of osteoblast functions and indirect inhibition of osteoclast activities. Considering growing evidence for their role in the metastatic cascade, platelets and/or megakaryocytes may provide new therapeutic opportunities to help limit bone metastases.

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References

Cheng Y, Streicher D, Waning D, Chitteti B, Gerard-ORiley R, Horowitz M . Signaling pathways involved in megakaryocyte-mediated proliferation of osteoblast lineage cells. J Cell Physiol. 2014; 230(3):578-86. PMC: 4433553. DOI: 10.1002/jcp.24774. View

Rickles F, Falanga A . Molecular basis for the relationship between thrombosis and cancer. Thromb Res. 2001; 102(6):V215-24. DOI: 10.1016/s0049-3848(01)00285-7. View

Erpenbeck L, Nieswandt B, Schon M, Pozgajova M, Schon M . Inhibition of platelet GPIb alpha and promotion of melanoma metastasis. J Invest Dermatol. 2009; 130(2):576-86. DOI: 10.1038/jid.2009.278. View

Camerer E, Qazi A, Duong D, Cornelissen I, Advincula R, Coughlin S . Platelets, protease-activated receptors, and fibrinogen in hematogenous metastasis. Blood. 2004; 104(2):397-401. DOI: 10.1182/blood-2004-02-0434. View

Kaushansky K . Thrombopoietin: the primary regulator of platelet production. Blood. 1995; 86(2):419-31. View

Shivdasani R . Molecular and transcriptional regulation of megakaryocyte differentiation. Stem Cells. 2001; 19(5):397-407. DOI: 10.1634/stemcells.19-5-397. View

Suva L, Hartman E, Dilley J, Russell S, Akel N, Skinner R . Platelet dysfunction and a high bone mass phenotype in a murine model of platelet-type von Willebrand disease. Am J Pathol. 2008; 172(2):430-9. PMC: 2312362. DOI: 10.2353/ajpath.2008.070417. View

Wakikawa T, Shioi A, Hino M, Inaba M, Nishizawa Y, Tatsumi N . Thrombopoietin inhibits in vitro osteoclastogenesis from murine bone marrow cells. Endocrinology. 1997; 138(10):4160-6. DOI: 10.1210/endo.138.10.5438. View

Uluckan O, Eagleton M, Floyd D, Morgan E, Hirbe A, Kramer M . APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice. J Cell Biochem. 2008; 104(4):1311-23. PMC: 2763643. DOI: 10.1002/jcb.21709. View

10.

Lin R, Afshar-Kharghan V, Schafer A . Paraneoplastic thrombocytosis: the secrets of tumor self-promotion. Blood. 2014; 124(2):184-7. PMC: 4093679. DOI: 10.1182/blood-2014-03-562538. View

11.

Karpatkin S, Pearlstein E, Ambrogio C, Coller B . Role of adhesive proteins in platelet tumor interaction in vitro and metastasis formation in vivo. J Clin Invest. 1988; 81(4):1012-9. PMC: 329625. DOI: 10.1172/JCI113411. View

12.

Laubli H, Borsig L . Selectins promote tumor metastasis. Semin Cancer Biol. 2010; 20(3):169-77. DOI: 10.1016/j.semcancer.2010.04.005. View

13.

Li X, Koh A, Wang Z, Soki F, Park S, Pienta K . Inhibitory effects of megakaryocytic cells in prostate cancer skeletal metastasis. J Bone Miner Res. 2010; 26(1):125-34. PMC: 3179321. DOI: 10.1002/jbmr.204. View

14.

Boucharaba A, Serre C, Gres S, Saulnier-Blache J, Bordet J, Guglielmi J . Platelet-derived lysophosphatidic acid supports the progression of osteolytic bone metastases in breast cancer. J Clin Invest. 2004; 114(12):1714-25. PMC: 535068. DOI: 10.1172/JCI22123. View

15.

Bakewell S, Nestor P, Prasad S, Tomasson M, Dowland N, Mehrotra M . Platelet and osteoclast beta3 integrins are critical for bone metastasis. Proc Natl Acad Sci U S A. 2003; 100(24):14205-10. PMC: 283570. DOI: 10.1073/pnas.2234372100. View

16.

Sharif P, Abdollahi M . The role of platelets in bone remodeling. Inflamm Allergy Drug Targets. 2010; 9(5):393-9. DOI: 10.2174/187152810793938044. View

17.

Leblanc R, Lee S, David M, Bordet J, Norman D, Patil R . Interaction of platelet-derived autotaxin with tumor integrin αVβ3 controls metastasis of breast cancer cells to bone. Blood. 2014; 124(20):3141-50. PMC: 4231421. DOI: 10.1182/blood-2014-04-568683. View

18.

Lyman G, Bohlke K, Khorana A, Kuderer N, Lee A, Arcelus J . Venous thromboembolism prophylaxis and treatment in patients with cancer: american society of clinical oncology clinical practice guideline update 2014. J Clin Oncol. 2015; 33(6):654-6. PMC: 4881372. DOI: 10.1200/JCO.2014.59.7351. View

19.

Weicht B, Maitz P, Kandler B, Fischer M, Watzek G, Gruber R . Activated platelets positively regulate RANKL-mediated osteoclast differentiation. J Cell Biochem. 2007; 102(5):1300-7. DOI: 10.1002/jcb.21360. View

20.

Menter D, Tucker S, Kopetz S, Sood A, Crissman J, Honn K . Platelets and cancer: a casual or causal relationship: revisited. Cancer Metastasis Rev. 2014; 33(1):231-69. PMC: 4186918. DOI: 10.1007/s10555-014-9498-0. View