The Microbiota and Chronic Kidney Diseases: a Double-edged Sword

Overview

Journal Clin Transl Immunology

Specialty Allergy & Immunology

Date 2016 Oct 21

PMID 27757226

Citations 32

Authors

Raphael Jose Ferreira Felizardo

Angela Castoldi

Vinicius Andrade-Oliveira

Niels Olsen Saraiva Camara

Affiliations

Soon will be listed here.

Abstract

Recent findings regarding the influence of the microbiota in many inflammatory processes have provided a new way to treat diseases. Now, one may hypothesize that the origin of a plethora of diseases is related to the health of the gut microbiota and its delicate, although complex, interface with the epithelial and immune systems. The 'westernization' of diets, for example, is associated with alterations in the gut microbiota. Such alterations have been found to correlate directly with the increased incidence of diabetes and hypertension, the main causes of chronic kidney diseases (CKDs), which, in turn, have a high estimated prevalence. Indeed, data have arisen showing that the progression of kidney diseases is strictly related to the composition of the microbiota. Alterations in the gut microbiota diversity during CKDs do not only have the potential to exacerbate renal injury but may also contribute to the development of associated comorbidities, such as cardiovascular diseases and insulin resistance. In this review, we discuss how dysbiosis through alterations in the gut barrier and the consequent activation of immune system could intensify the progression of CKD and vice versa, how CKDs can modify the gut microbiota diversity and abundance.

Citing Articles

Characteristics and function of the gut microbiota in patients with IgA nephropathy via metagenomic sequencing technology.

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Yi-Shen-Hua-Shi regulates intestinal microbiota dysbiosis and protects against proteinuria in patients with chronic kidney disease: a randomized controlled study.

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Causal relationship between gut microbiota and kidney diseases: a two-sample Mendelian randomization study.

Feng Z, Zhang Y, Lai Y, Jia C, Wu F, Chen D Front Immunol. 2024; 14:1277554.

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Editorial: Global excellence in renal pharmacology 2022: Central and South America.

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PMID: 38269280 PMC: 10807036. DOI: 10.3389/fphar.2023.1362010.

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