Editorial: The Role of the Plasminogen Activating System in Neurobiology

Overview

Journal Front Cell Neurosci

Specialty Cell Biology

Date 2016 Oct 21

PMID 27757075

Citations 2

Authors

Robert L Medcalf

Daniel A Lawrence

Affiliations

Soon will be listed here.

Citing Articles

The Development of Novel Drug Treatments for Stroke Patients: A Review.

Frank D, Zlotnik A, Boyko M, Gruenbaum B Int J Mol Sci. 2022; 23(10).

PMID: 35628606 PMC: 9145977. DOI: 10.3390/ijms23105796.

Dysregulation of complement and coagulation pathways: emerging mechanisms in the development of psychosis.

Heurich M, Focking M, Mongan D, Cagney G, Cotter D Mol Psychiatry. 2021; 27(1):127-140.

PMID: 34226666 PMC: 8256396. DOI: 10.1038/s41380-021-01197-9.

References

Fredriksson L, Li H, Fieber C, Li X, Eriksson U . Tissue plasminogen activator is a potent activator of PDGF-CC. EMBO J. 2004; 23(19):3793-802. PMC: 522796. DOI: 10.1038/sj.emboj.7600397. View

Niego B, Freeman R, Puschmann T, Turnley A, Medcalf R . t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes. Blood. 2012; 119(20):4752-61. DOI: 10.1182/blood-2011-07-369512. View

Soreq H, Miskin R . Plasminogen activator in the rodent brain. Brain Res. 1981; 216(2):361-74. DOI: 10.1016/0006-8993(81)90138-4. View

Kim Y, Park J, Hong S, Koh J . Nonproteolytic neuroprotection by human recombinant tissue plasminogen activator. Science. 1999; 284(5414):647-50. DOI: 10.1126/science.284.5414.647. View

Fredriksson L, Lawrence D, Medcalf R . tPA Modulation of the Blood-Brain Barrier: A Unifying Explanation for the Pleiotropic Effects of tPA in the CNS. Semin Thromb Hemost. 2016; 43(2):154-168. PMC: 5848490. DOI: 10.1055/s-0036-1586229. View

. Tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995; 333(24):1581-7. DOI: 10.1056/NEJM199512143332401. View

Medcalf R . Fibrinolysis, inflammation, and regulation of the plasminogen activating system. J Thromb Haemost. 2007; 5 Suppl 1:132-42. DOI: 10.1111/j.1538-7836.2007.02464.x. View

Matys T, Strickland S . Tissue plasminogen activator and NMDA receptor cleavage. Nat Med. 2003; 9(4):371-2; author reply 372-3. DOI: 10.1038/nm0403-371. View

Yepes M, Lawrence D . New functions for an old enzyme: nonhemostatic roles for tissue-type plasminogen activator in the central nervous system. Exp Biol Med (Maywood). 2004; 229(11):1097-104. DOI: 10.1177/153537020422901103. View

10.

Echeverry R, Wu J, Haile W, Guzman J, Yepes M . Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus. J Clin Invest. 2010; 120(6):2194-205. PMC: 2877952. DOI: 10.1172/JCI41722. View

11.

Samson A, Nevin S, Croucher D, Niego B, Daniel P, Weiss T . Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function. J Neurochem. 2008; 107(4):1091-101. PMC: 3198853. DOI: 10.1111/j.1471-4159.2008.05687.x. View

12.

Seeds N, Basham M, Ferguson J . Absence of tissue plasminogen activator gene or activity impairs mouse cerebellar motor learning. J Neurosci. 2003; 23(19):7368-75. PMC: 6740439. View

13.

Kidwell C, Latour L, Saver J, Alger J, Starkman S, Duckwiler G . Thrombolytic toxicity: blood brain barrier disruption in human ischemic stroke. Cerebrovasc Dis. 2008; 25(4):338-43. DOI: 10.1159/000118379. View

14.

Yepes M, Sandkvist M, Moore E, Bugge T, Strickland D, Lawrence D . Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J Clin Invest. 2003; 112(10):1533-40. PMC: 259131. DOI: 10.1172/JCI19212. View

15.

Sashindranath M, Sales E, Daglas M, Freeman R, Samson A, Cops E . The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans. Brain. 2012; 135(Pt 11):3251-64. PMC: 3501968. DOI: 10.1093/brain/aws178. View

16.

Krystosek A, Seeds N . Plasminogen activator secretion by granule neurons in cultures of developing cerebellum. Proc Natl Acad Sci U S A. 1981; 78(12):7810-4. PMC: 349361. DOI: 10.1073/pnas.78.12.7810. View

17.

Seeds N, Williams B, Bickford P . Tissue plasminogen activator induction in Purkinje neurons after cerebellar motor learning. Science. 1995; 270(5244):1992-4. DOI: 10.1126/science.270.5244.1992. View

18.

Niego B, Medcalf R . Plasmin-dependent modulation of the blood-brain barrier: a major consideration during tPA-induced thrombolysis?. J Cereb Blood Flow Metab. 2014; 34(8):1283-96. PMC: 4126105. DOI: 10.1038/jcbfm.2014.99. View

19.

Nicole O, Docagne F, Ali C, Margaill I, Carmeliet P, MacKenzie E . The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling. Nat Med. 2001; 7(1):59-64. DOI: 10.1038/83358. View

20.

Maiya R, Zhou Y, Norris E, Kreek M, Strickland S . Tissue plasminogen activator modulates the cellular and behavioral response to cocaine. Proc Natl Acad Sci U S A. 2009; 106(6):1983-8. PMC: 2644150. DOI: 10.1073/pnas.0812491106. View