The Association Between Dietary Vitamin A Intake and Pancreatic Cancer Risk: a Meta-analysis of 11 Studies

Overview

Journal Biosci Rep

Specialty Cell Biology

Date 2016 Oct 21

PMID 27756825

Citations 9

Authors

Tao Zhang

Hongqiang Chen

Shiyong Qin

Minghai Wang

Xianming Wang

Xin Zhang

Fei Liu

Shuguang Zhang

Affiliations

Soon will be listed here.

Abstract

Whether dietary vitamin A intake could reduce pancreatic cancer risk is still conflicting. We therefore conducted a meta-analysis to summarize the evidence from epidemiological studies. We searched the databases of PubMed and Web of Knowledge up to July 2016. Random model was used to combine study-specific relative risks (RR) and 95% confidence interval (CI). Publication bias was assessed by Egger regression asymmetry test and Begg's funnel plot. Eleven studies (10 case-control studies and 1 cohort study) involving 2705 pancreatic cancer cases were included in the present study. The RR (95% CI) of pancreatic cancer for highest category of vitamin A intake compared with lowest category was 0.839 (95% CI=0.712-0.988) with low heterogeneity detected (I=17.8%, P=0.274). The relationships were also significant for studies designed by case-control [RR=0.808, 95% CI=0.690-0.947], as well as in European population [RR=0.821, 95% CI=0.693-0.972]. No evidence of publication bias was found. This meta-analysis demonstrated that dietary vitamin A intake might inversely associated with the risk of pancreatic cancer.

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