In Vitro Study on Anti-Hepatitis C Virus Activity of Spatholobus Suberectus Dunn

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2016 Oct 19

PMID 27754461

Citations 16

Authors

Shao-Ru Chen

An-Qi Wang

Li-Gen Lin

Hong-Cong Qiu

Yi-Tao Wang

Ying Wang

Affiliations

Soon will be listed here.

Abstract

Hepatitis C virus (HCV) infects 200 million people worldwide, and 75% of HCV cases progress into chronic infections, which consequently cause cirrhosis and hepatocellular carcinoma. HCV infection is treated with currently considered standard drugs, including direct anti-viral agents (DAAs), alone or in combination with peginterferon-α plus ribavirin. However, sustained viral responses vary in different cohorts, and high costs limit the broad use of DAAs. In this study, the ethanol and water extracts of 12 herbs from Lingnan in China were examined in terms of their inhibitory effect on HCV replication. Among the examined extracts, ethanol extracts suppressed HCV replication. By comparison, Extracts from , (root), (fruit), (flower), (seed), Thunb (flower), Thunb (fruit), (sclerotia), L. (flower), (fruit), and Houtt. (leaf) extracts failed to show a similar activity. Active fractions containing tannins as the major component also inhibited the in vitro translation of HCV RNA. The combination treatments of single compounds, such as epigallocatechin gallate and epicatechin gallate, were not as potent as crude fractions; therefore, crude extract may be a potential alternative treatment against HCV either alone or in combination with other agents.

Citing Articles

Self-healing hydrogels loaded with Spatholobi Caulis alleviate disc degeneration by promoting autophagy in nucelus pulposus.

Cai S, Ding R, Zhang H, Chen Q, Yu F, Xia Y Mater Today Bio. 2024; 29:101323.

PMID: 39624051 PMC: 11609258. DOI: 10.1016/j.mtbio.2024.101323.

inhibits lipogenesis and tumorigenesis in triple-negative breast cancer via activation of AMPK-ACC and K-Ras-ERK signaling pathway.

Zeng X, Gong G, Ganesan K, Wen Y, Liu Q, Zhuo J J Tradit Complement Med. 2023; 13(6):623-638.

PMID: 38020549 PMC: 10658394. DOI: 10.1016/j.jtcme.2023.09.002.

Pharmacodynamic Material Basis and Potential Mechanism Study of Spatholobi Caulis in Reversing Osteoporosis.

Xiao J, Shang W, Zhao Z, Jiang J, Chen J, Cai H Evid Based Complement Alternat Med. 2023; 2023:3071147.

PMID: 37089711 PMC: 10121353. DOI: 10.1155/2023/3071147.

A comparative study on photosynthetic characteristics and flavonoid metabolism between (Merr.) Sealy and Chang &Liang.

Huang X, Qin B, Qin L, Peng Z, Xia S, Su Y Front Plant Sci. 2022; 13:1071458.

PMID: 36544877 PMC: 9762238. DOI: 10.3389/fpls.2022.1071458.

Coordination of AMPK and YAP by and Procyanidin B2 Provides Antioxidant Effects In Vitro and In Vivo.

Bae S, Bak S, Kim Y Int J Mol Sci. 2022; 23(22).

PMID: 36430207 PMC: 9694094. DOI: 10.3390/ijms232213730.

References

Ahmed-Belkacem A, Guichou J, Brillet R, Ahnou N, Hernandez E, Pallier C . Inhibition of RNA binding to hepatitis C virus RNA-dependent RNA polymerase: a new mechanism for antiviral intervention. Nucleic Acids Res. 2014; 42(14):9399-409. PMC: 4132742. DOI: 10.1093/nar/gku632. View

Park K, Choi Y, Park J . Enterovirus infection in Korean children and anti-enteroviral potential candidate agents. Korean J Pediatr. 2012; 55(10):359-66. PMC: 3488610. DOI: 10.3345/kjp.2012.55.10.359. View

Berg T, Sarrazin C, Herrmann E, Hinrichsen H, Gerlach T, Zachoval R . Prediction of treatment outcome in patients with chronic hepatitis C: significance of baseline parameters and viral dynamics during therapy. Hepatology. 2003; 37(3):600-9. DOI: 10.1053/jhep.2003.50106. View

Forns X, Lawitz E, Zeuzem S, Gane E, Bronowicki J, Andreone P . Simeprevir with peginterferon and ribavirin leads to high rates of SVR in patients with HCV genotype 1 who relapsed after previous therapy: a phase 3 trial. Gastroenterology. 2014; 146(7):1669-79.e3. DOI: 10.1053/j.gastro.2014.02.051. View

Yan L, Ruan J, Zhang L, Fan F, Zhang F, Wang A . Effect of aqueous extracts of several kinds of herbs on human platelet aggregation and expression of P-selectin in vitro. Chin J Integr Med. 2014; 21(4):286-90. DOI: 10.1007/s11655-013-1540-5. View

Hnatyszyn H . Chronic hepatitis C and genotyping: the clinical significance of determining HCV genotypes. Antivir Ther. 2005; 10(1):1-11. View

Li Y, Ramirez S, Jensen S, Purcell R, Gottwein J, Bukh J . Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system. Proc Natl Acad Sci U S A. 2012; 109(48):19757-62. PMC: 3511766. DOI: 10.1073/pnas.1218260109. View

Zhuang X, Wang Y, Chow E, Liang Y, Wilson D, Zhang L . Risk factors associated with HIV/HCV infection among entrants in methadone maintenance treatment clinics in China: a systematic review and meta-analysis. Drug Alcohol Depend. 2012; 126(3):286-95. DOI: 10.1016/j.drugalcdep.2012.05.028. View

Fried M, Navarro V, Afdhal N, Belle S, Wahed A, Hawke R . Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. JAMA. 2012; 308(3):274-82. PMC: 3683986. DOI: 10.1001/jama.2012.8265. View

10.

Takeshita M, Ishida Y, Akamatsu E, Ohmori Y, Sudoh M, Uto H . Proanthocyanidin from blueberry leaves suppresses expression of subgenomic hepatitis C virus RNA. J Biol Chem. 2009; 284(32):21165-76. PMC: 2755839. DOI: 10.1074/jbc.M109.004945. View

11.

Lee J, Bae S, Oh M, Kim K, Chung M . Antiviral effects of mulberry (Morus alba) juice and its fractions on foodborne viral surrogates. Foodborne Pathog Dis. 2013; 11(3):224-9. DOI: 10.1089/fpd.2013.1633. View

12.

Hsu W, Chang S, Lin L, Li C, Richardson C, Lin C . Limonium sinense and gallic acid suppress hepatitis C virus infection by blocking early viral entry. Antiviral Res. 2015; 118:139-47. DOI: 10.1016/j.antiviral.2015.04.003. View

13.

Liu Y, Wang F, Wang G, Han J, Wang Y, Wang Y . In vivo anthelmintic activity of crude extracts of Radix angelicae pubescentis, Fructus bruceae, Caulis spatholobi, Semen aesculi, and Semen pharbitidis against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus). Parasitol Res. 2010; 106(5):1233-9. DOI: 10.1007/s00436-010-1799-9. View

14.

Liu B, Liu J, Chen J, Zhu D, Zhou H, Wang X . A study on anticancer activity of Caulis Spatholobi extract on human osteosarcoma Saos-2 cells. Afr J Tradit Complement Altern Med. 2013; 10(5):256-60. PMC: 3847413. DOI: 10.4314/ajtcam.v10i5.6. View

15.

Dai W, Li G, Li X, Hu Q, Liu J, Zhang F . The roots of Ilex asprella extract lessens acute respiratory distress syndrome in mice induced by influenza virus. J Ethnopharmacol. 2014; 155(3):1575-82. DOI: 10.1016/j.jep.2014.07.051. View

16.

Kau A, Vermehren J, Sarrazin C . Treatment predictors of a sustained virologic response in hepatitis B and C. J Hepatol. 2008; 49(4):634-51. DOI: 10.1016/j.jhep.2008.07.013. View

17.

Uma Reddy B, Mullick R, Kumar A, Sudha G, Srinivasan N, Das S . Small molecule inhibitors of HCV replication from pomegranate. Sci Rep. 2014; 4:5411. PMC: 4067622. DOI: 10.1038/srep05411. View

18.

Afdhal N, Reddy K, Nelson D, Lawitz E, Gordon S, Schiff E . Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection. N Engl J Med. 2014; 370(16):1483-93. DOI: 10.1056/NEJMoa1316366. View

19.

Fu Y, Qin W, Cao H, Xu R, Tan Y, Lu T . HCV 6a prevalence in Guangdong province had the origin from Vietnam and recent dissemination to other regions of China: phylogeographic analyses. PLoS One. 2012; 7(1):e28006. PMC: 3253785. DOI: 10.1371/journal.pone.0028006. View

20.

Jardim A, Igloi Z, Shimizu J, Santos V, Felippe L, Mazzeu B . Natural compounds isolated from Brazilian plants are potent inhibitors of hepatitis C virus replication in vitro. Antiviral Res. 2015; 115:39-47. PMC: 4329992. DOI: 10.1016/j.antiviral.2014.12.018. View