Effect of Genetic Polymorphisms and Long-Term Tobacco Exposure on the Risk of Breast Cancer

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2016 Oct 19

PMID 27754415

Citations 3

Authors

Zoraida Verde

Catalina Santiago

Luis Miguel Chicharro

Luis Reinoso-Barbero

Alejandro Tejerina

Fernando Bandres

Felix Gomez-Gallego

Affiliations

Soon will be listed here.

Abstract

Introduction: Tobacco smoke contains many potentially harmful compounds that may act differently and at different stages in breast cancer development. The focus of this work was to assess the possible role of cigarette smoking (status, dose, duration or age at initiation) and polymorphisms in genes coding for enzymes involved in tobacco carcinogen metabolism (, ) or in DNA repair (, , and ) in breast cancer development.

Methods: We designed a case control study with 297 patients, 217 histologically verified breast cancers (141 smokers and 76 non-smokers) and 80 healthy smokers in a cohort of Spanish women.

Results: We found an association between smoking status and early age at diagnosis of breast cancer. Among smokers, invasive carcinoma subtype incidence increased with intensity and duration of smoking (all < 0.05). When smokers were stratified by smoking duration, we only observed differences in long-term smokers, and the genotype was associated with increased risk of breast cancer (OR = 7.12 (1.98-25.59)).

Conclusions: Our results support the main effect of CYP1A1 in estrogenic metabolism rather than in tobacco carcinogen activation in breast cancer patients and also confirmed the hypothesis that , in association with long periods of active smoking, could be a breast cancer risk factor.

Citing Articles

Association between tobacco substance usage and a missense mutation in the tumor suppressor gene P53 in the Saudi Arabian population.

Almutairi M, Almutairi B, Alrubie T, Alharbi S, Parine N, Alrefaei A PLoS One. 2021; 16(1):e0245133.

PMID: 33481818 PMC: 7822264. DOI: 10.1371/journal.pone.0245133.

Effect of the thymine-DNA glycosylase rs4135050 variant on Saudi smoker population.

Almutairi M, Mohammad Alhadeq A, Almeer R, Almutairi M, Alzahrani M, Semlali A Mol Genet Genomic Med. 2019; 7(4):e00590.

PMID: 30779328 PMC: 6465727. DOI: 10.1002/mgg3.590.

Association of Cytochrome Gene Polymorphisms and Tobacco Smoking With the Risk of Breast Cancer in Women From Iraq.

Naif H, Al-Obaide M, Hassani H, Hamdan A, Kalaf Z Front Public Health. 2018; 6:96.

PMID: 29707532 PMC: 5906712. DOI: 10.3389/fpubh.2018.00096.

References

Kisselev P, Schunck W, Roots I, Schwarz D . Association of CYP1A1 polymorphisms with differential metabolic activation of 17beta-estradiol and estrone. Cancer Res. 2005; 65(7):2972-8. DOI: 10.1158/0008-5472.CAN-04-3543. View

Cox Jr L . Low-dose nonlinear effects of smoking on coronary heart disease risk. Dose Response. 2012; 10(2):219-32. PMC: 3375489. DOI: 10.2203/dose-response.11-038.Cox. View

Stephenson N, Beckmann L, Chang-Claude J . Carcinogen metabolism, cigarette smoking, and breast cancer risk: a Bayes model averaging approach. Epidemiol Perspect Innov. 2010; 7:10. PMC: 2999590. DOI: 10.1186/1742-5573-7-10. View

Marcus P, Hayes R, Vineis P, Garcia-Closas M, Caporaso N, Autrup H . Cigarette smoking, N-acetyltransferase 2 acetylation status, and bladder cancer risk: a case-series meta-analysis of a gene-environment interaction. Cancer Epidemiol Biomarkers Prev. 2000; 9(5):461-7. View

Nebert D, Wikvall K, Miller W . Human cytochromes P450 in health and disease. Philos Trans R Soc Lond B Biol Sci. 2013; 368(1612):20120431. PMC: 3538421. DOI: 10.1098/rstb.2012.0431. View

Cooper J, Rohan T, Cant E, Horsfall D, Tilley W . Risk factors for breast cancer by oestrogen receptor status: a population-based case-control study. Br J Cancer. 1989; 59(1):119-25. PMC: 2246966. DOI: 10.1038/bjc.1989.24. View

Shizu M, Itoh Y, Sunahara R, Chujo S, Hayashi H, Ide Y . Cigarette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line. J Interferon Cytokine Res. 2008; 28(8):509-21. DOI: 10.1089/jir.2007.0081. View

Hunter D, Hankinson S, Hough H, Gertig D, Garcia-Closas M, Spiegelman D . A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer. Carcinogenesis. 1997; 18(11):2127-32. DOI: 10.1093/carcin/18.11.2127. View

McManus M, Burgess W, Veronese M, Huggett A, Quattrochi L, Tukey R . Metabolism of 2-acetylaminofluorene and benzo(a)pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P-450. Cancer Res. 1990; 50(11):3367-76. View

10.

Gaudet M, Gapstur S, Sun J, Diver W, Hannan L, Thun M . Active smoking and breast cancer risk: original cohort data and meta-analysis. J Natl Cancer Inst. 2013; 105(8):515-25. DOI: 10.1093/jnci/djt023. View

11.

Young E, Leatherdale S, Sloan M, Kreiger N, Barisic A . Age of smoking initiation and risk of breast cancer in a sample of Ontario women. Tob Induc Dis. 2009; 5(1):4. PMC: 2656478. DOI: 10.1186/1617-9625-5-4. View

12.

Miyoshi Y, Takahashi Y, Egawa C, Noguchi S . Breast cancer risk associated with CYP1A1 genetic polymorphisms in Japanese women. Breast J. 2002; 8(4):209-15. DOI: 10.1046/j.1524-4741.2002.08404.x. View

13.

. WHO urges more countries to require large, graphic health warnings on tobacco packaging: the WHO report on the global tobacco epidemic, 2011 examines anti-tobacco mass-media campaigns. Cent Eur J Public Health. 2011; 19(3):133, 151. View

14.

Godtfredsen N, Holst C, Prescott E, Vestbo J, Osler M . Smoking reduction, smoking cessation, and mortality: a 16-year follow-up of 19,732 men and women from The Copenhagen Centre for Prospective Population Studies. Am J Epidemiol. 2002; 156(11):994-1001. DOI: 10.1093/aje/kwf150. View

15.

Verde Z, Reinoso-Barbero L, Chicharro L, Garatachea N, Resano P, Sanchez-Hernandez I . Effects of cigarette smoking and nicotine metabolite ratio on leukocyte telomere length. Environ Res. 2015; 140:488-94. DOI: 10.1016/j.envres.2015.05.008. View

16.

Russo A, Thiagalingam A, Pan H, Califano J, Cheng K, Ponte J . Differential DNA hypermethylation of critical genes mediates the stage-specific tobacco smoke-induced neoplastic progression of lung cancer. Clin Cancer Res. 2005; 11(7):2466-70. DOI: 10.1158/1078-0432.CCR-04-1962. View

17.

Monostory K, Dvorak Z . Steroid regulation of drug-metabolizing cytochromes P450. Curr Drug Metab. 2011; 12(2):154-72. DOI: 10.2174/138920011795016854. View

18.

Cox D, Dostal L, Hunter D, Le Marchand L, Hoover R, Ziegler R . N-acetyltransferase 2 polymorphisms, tobacco smoking, and breast cancer risk in the breast and prostate cancer cohort consortium. Am J Epidemiol. 2011; 174(11):1316-22. PMC: 3390163. DOI: 10.1093/aje/kwr257. View

19.

Miyoshi Y, Noguchi S . Polymorphisms of estrogen synthesizing and metabolizing genes and breast cancer risk in Japanese women. Biomed Pharmacother. 2003; 57(10):471-81. DOI: 10.1016/j.biopha.2003.09.008. View

20.

Kasajova P, Holubekova V, Mendelova A, Lasabova Z, Zubor P, Kudela E . Active cigarette smoking and the risk of breast cancer at the level of N-acetyltransferase 2 (NAT2) gene polymorphisms. Tumour Biol. 2015; 37(6):7929-37. DOI: 10.1007/s13277-015-4685-3. View