Outcome and Current Status of Therapeutic Hypothermia After Out-of-hospital Cardiac Arrest in Korea Using Data from the Korea Hypothermia Network Registry

Overview

Journal Clin Exp Emerg Med

Specialty Emergency Medicine

Date 2014 Sep 30

PMID 27752548

Citations 12

Authors

Byung Kook Lee

Kyu Nam Park

Gu Hyun Kang

Kyung Hwan Kim

Giwoon Kim

Won Young Kim

Jin Hong Min

Yooseok Park

Jung Bae Park

Gil Joon Suh

Yoo Dong Son

Jonghwan Shin

Joo Suk Oh

Yeon Ho You

Dong Hoon Lee

Jong Seok Lee

Hoon Lim

Tae Chang Jang

Gyu Chong Cho

In Soo Cho

Kyoung Chul Cha

Seung Pill Choi

Wook Jin Choi

Chul Han

Affiliations

Soon will be listed here.

Abstract

Objective: Therapeutic hypothermia (TH) has become the standard strategy for reducing brain damage in the postresuscitation period. The aim of this study was to investigate current TH performance and outcomes in out-of-hospital cardiac arrest (OHCA) survivors using data from the Korean Hypothermia Network (KORHN) registry.

Methods: We used the KORHN registry, a web-based multicenter registry that includes 24 participating hospitals throughout the Republic of Korea. Adult comatose OHCA survivors treated with TH between 2007 and 2012 were included. The primary outcomes were neurological outcome at hospital discharge and in-hospital mortality. The secondary outcomes were TH performance and adverse events during TH.

Results: A total of 930 patients were included, of whom 556 (59.8%) survived to discharge and 249 (26.8%) were discharged with good neurologic outcomes. The median time from return of spontaneous circulation (ROSC) to the start of TH was 101 minutes (interquartile range [IQR], 46 to 200 minutes). The induction, maintenance, and rewarming durations were 150 minutes (IQR, 80 to 267 minutes), 1,440 minutes (IQR, 1,290 to 1,440 minutes), and 708 minutes (IQR, 420 to 900 minutes), respectively. The time from the ROSC to coronary angiography was 1,045 hours (IQR, 121 to 12,051 hours). Hyperglycemia (46.3%) was the most frequent adverse event.

Conclusion: More than one-quarter of the OHCA survivors (26.8%) were discharged with good neurologic outcomes. TH performance was appropriately managed in terms of the factors related to its timing, including cooling start time and rewarming duration.

Citing Articles

Feasibility of Magnetic Resonance-Based Conductivity Imaging as a Tool to Estimate the Severity of Hypoxic-Ischemic Brain Injury in the First Hours After Cardiac Arrest.

Jung Y, Lee H, Lee B, Choi B, Kim T, Kim J Neurocrit Care. 2023; 40(2):538-550.

PMID: 37353670 DOI: 10.1007/s12028-023-01776-4.

Brain Death and Its Prediction in Out-of-Hospital Cardiac Arrest Patients Treated with Targeted Temperature Management.

Song H, Oh S, Woo H, Crown Investigators Diagnostics (Basel). 2022; 12(5).

PMID: 35626345 PMC: 9140750. DOI: 10.3390/diagnostics12051190.

Outcome and status of postcardiac arrest care in Korea: results from the Korean Hypothermia Network prospective registry.

Kim S, Park K, Youn C, Chae M, Kim W, Lee B Clin Exp Emerg Med. 2021; 7(4):250-258.

PMID: 33440102 PMC: 7808836. DOI: 10.15441/ceem.20.035.

Prognostic Factors for Re-Arrest with Shockable Rhythm during Target Temperature Management in Out-Of-Hospital Shockable Cardiac Arrest Patients.

Ryoo S, Lee D, Lee B, Youn C, Kim Y, Kim S J Clin Med. 2019; 8(9).

PMID: 31480615 PMC: 6780596. DOI: 10.3390/jcm8091360.

Recovery from acute kidney injury as a potent predictor of survival and good neurological outcome at discharge after out-of-hospital cardiac arrest.

Park Y, Choi Y, Oh J, Cho I, Cha K, Choi B Crit Care. 2019; 23(1):256.

PMID: 31307504 PMC: 6632185. DOI: 10.1186/s13054-019-2535-1.

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