Respiratory Training in an Individual with Amyotrophic Lateral Sclerosis

Overview

Journal Ann Clin Transl Neurol

Specialty Neurology

Date 2016 Oct 19

PMID 27752517

Citations 9

Authors

Lauren C Tabor

Karen M Rosado

Raele Robison

Karen Hegland

Ianessa A Humbert

Emily K Plowman

Affiliations

Soon will be listed here.

Abstract

We examined the impact of expiratory muscle strength training on maximum expiratory pressure, cough spirometry, and disease progression in a 71-year-old male with amyotrophic lateral sclerosis. Maximum expiratory pressure declined 9% over an 8-week sham training period, but subsequently improved by 102% following 8 weeks of expiratory muscle strength training. Improvements in cough spirometry and mitigated disease progression were also observed post expiratory muscle strength training. Improvements in maximum expiratory pressures were maintained 6 months following expiratory muscle strength training and were 79% higher than baseline data obtained 301 days prior. In this spinal-onset amyotrophic lateral sclerosis patient, respiratory training improved subglottic air pressure generation and sequential cough generation.

Citing Articles

Future Directions for Respiratory Muscle Training in Neuromuscular Disorders: A Scoping Review.

van Kleef E, Poddighe D, Caleffi Pereira M, Schuurbiers M, Groothuis J, Wijkstra P Respiration. 2024; 103(10):601-621.

PMID: 38857581 PMC: 11446296. DOI: 10.1159/000539726.

Efficacy of non-pharmacological interventions for individuals with amyotrophic lateral sclerosis: systematic review and network meta-analysis of randomized control trials.

Li Z, Kang H Sci Rep. 2024; 14(1):11365.

PMID: 38762656 PMC: 11102473. DOI: 10.1038/s41598-024-62213-w.

Relationship between pulmonary, cough, and swallowing functions in individuals with amyotrophic lateral sclerosis.

Donohue C, Vasilopoulos T, Wymer J, Plowman E Muscle Nerve. 2024; 70(1):140-147.

PMID: 38742544 PMC: 11152987. DOI: 10.1002/mus.28113.

A meta-analysis of post-exercise outcomes in people with amyotrophic lateral sclerosis.

Donohue C, Carnaby G, Reilly M, Colquhoun R, Lacomis D, Garand K eNeurologicalSci. 2023; 31:100452.

PMID: 36875937 PMC: 9982645. DOI: 10.1016/j.ensci.2023.100452.

Home-Based Music Therapy to Support Bulbar and Respiratory Functions of Persons with Early and Mid-Stage Amyotrophic Lateral Sclerosis-Protocol and Results from a Feasibility Study.

Apreleva Kolomeytseva A, Brylev L, Eshghi M, Bottaeva Z, Zhang J, Fachner J Brain Sci. 2022; 12(4).

PMID: 35448025 PMC: 9027911. DOI: 10.3390/brainsci12040494.

References

Carreras I, Yuruker S, Aytan N, Hossain L, Choi J, Jenkins B . Moderate exercise delays the motor performance decline in a transgenic model of ALS. Brain Res. 2009; 1313:192-201. PMC: 2892864. DOI: 10.1016/j.brainres.2009.11.051. View

Laciuga H, Rosenbek J, Davenport P, Sapienza C . Functional outcomes associated with expiratory muscle strength training: narrative review. J Rehabil Res Dev. 2014; 51(4):535-46. DOI: 10.1682/JRRD.2013.03.0076. View

Albert S, Murphy P, Del Bene M, Rowland L . Prospective study of palliative care in ALS: choice, timing, outcomes. J Neurol Sci. 1999; 169(1-2):108-13. DOI: 10.1016/s0022-510x(99)00227-0. View

Cheah B, Boland R, Brodaty N, Zoing M, Jeffery S, McKenzie D . INSPIRATIonAL--INSPIRAtory muscle training in amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2009; 10(5-6):384-92. DOI: 10.3109/17482960903082218. View

Tabor L, Gaziano J, Watts S, Robison R, Plowman E . Defining Swallowing-Related Quality of Life Profiles in Individuals with Amyotrophic Lateral Sclerosis. Dysphagia. 2016; 31(3):376-82. PMC: 4871719. DOI: 10.1007/s00455-015-9686-2. View

Brooks B, Miller R, Swash M, Munsat T . El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 2001; 1(5):293-9. DOI: 10.1080/146608200300079536. View

Plowman E, Watts S, Robison R, Tabor L, Dion C, Gaziano J . Voluntary Cough Airflow Differentiates Safe Versus Unsafe Swallowing in Amyotrophic Lateral Sclerosis. Dysphagia. 2016; 31(3):383-90. PMC: 4871758. DOI: 10.1007/s00455-015-9687-1. View

Plowman E, Watts S, Tabor L, Robison R, Gaziano J, Domer A . Impact of expiratory strength training in amyotrophic lateral sclerosis. Muscle Nerve. 2015; 54(1):48-53. PMC: 4879103. DOI: 10.1002/mus.24990. View

Plowman E . Is There a Role for Exercise in the Management of Bulbar Dysfunction in Amyotrophic Lateral Sclerosis?. J Speech Lang Hear Res. 2015; 58(4):1151-66. DOI: 10.1044/2015_JSLHR-S-14-0270. View

10.

Haas C, Loik P, Gay S . Airway clearance applications in the elderly and in patients with neurologic or neuromuscular compromise. Respir Care. 2007; 52(10):1362-81. View

11.

Hegland K, Troche M, Davenport P . Cough expired volume and airflow rates during sequential induced cough. Front Physiol. 2013; 4:167. PMC: 3701804. DOI: 10.3389/fphys.2013.00167. View

12.

Chen A, Garrett C . Otolaryngologic presentations of amyotrophic lateralsclerosis. Otolaryngol Head Neck Surg. 2005; 132(3):500-4. DOI: 10.1016/j.otohns.2004.09.092. View

13.

Cedarbaum J, Stambler N, Malta E, Fuller C, Hilt D, Thurmond B . The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III). J Neurol Sci. 1999; 169(1-2):13-21. DOI: 10.1016/s0022-510x(99)00210-5. View

14.

Troche M, Okun M, Rosenbek J, Musson N, Fernandez H, Rodriguez R . Aspiration and swallowing in Parkinson disease and rehabilitation with EMST: a randomized trial. Neurology. 2010; 75(21):1912-9. PMC: 2995389. DOI: 10.1212/WNL.0b013e3181fef115. View

15.

Neder J, Andreoni S, Lerario M, Nery L . Reference values for lung function tests. II. Maximal respiratory pressures and voluntary ventilation. Braz J Med Biol Res. 1999; 32(6):719-27. DOI: 10.1590/s0100-879x1999000600007. View

16.

Lyall R, Donaldson N, Polkey M, Leigh P, Moxham J . Respiratory muscle strength and ventilatory failure in amyotrophic lateral sclerosis. Brain. 2001; 124(Pt 10):2000-13. DOI: 10.1093/brain/124.10.2000. View

17.

Polkey M, Lyall R, Green M, Leigh P, Moxham J . Expiratory muscle function in amyotrophic lateral sclerosis. Am J Respir Crit Care Med. 1998; 158(3):734-41. DOI: 10.1164/ajrccm.158.3.9710072. View

18.

Schiffman P, Belsh J . Pulmonary function at diagnosis of amyotrophic lateral sclerosis. Rate of deterioration. Chest. 1993; 103(2):508-13. DOI: 10.1378/chest.103.2.508. View