» Articles » PMID: 2774657

Biologic Roles of the Innermost Cell Layer of the Outer Root Sheath in Human Anagen Hair Follicle: Further Electron Microscopic Study

Overview
Specialty Dermatology
Date 1989 Jan 1
PMID 2774657
Citations 3
Authors
Affiliations
Soon will be listed here.
Abstract

To elucidate the biologic roles and further cytologic characteristics of the innermost cell (IMC) layer of the outer root sheath (ORS), human anagen hair follicles were ultrastructurally examined. In the lower follicle, the transeversely running tonofilaments in the inner side of the cytoplasm of the IMCs showed a massive accumulation, facing the keratinized part of a Huxley's cell protruding through a Henle's pore. In a rare instance, a spindle-shaped cell was seen between the IMC layer and the keratinized Henle's layer. At the lower isthmus portion, some of the IMCs containing a large number of tonofilaments showed a partial degeneration of the inner side of the cytoplasm. More distally, intercellular spaces between the keratinized IMCs and keratinized Henle's cells were partly dilated and contained amorphous substances. It is suggested that the IMCs in the lower follicle may play a role to support and cover the inner hair structures, tightly as hoops of a barrel. In the isthmus portion, the IMCs may loosely support and guide the keratinized Henle's cells undergoing degeneration.

Citing Articles

Mouse models for human hair loss disorders.

Porter R J Anat. 2003; 202(1):125-31.

PMID: 12587927 PMC: 1571051. DOI: 10.1046/j.1469-7580.2003.00140.x.


Unusual distribution of melanocytes in hair bulbs from a Negro subject.

Ito M Arch Dermatol Res. 1991; 283(4):274-7.

PMID: 1929547 DOI: 10.1007/BF01106115.


Differential analysis of the human anagen hair apparatus using lectin binding histochemistry.

Tezuka M, Ito M, Ito K, Tazawa T, Sato Y Arch Dermatol Res. 1991; 283(3):180-5.

PMID: 1867481 DOI: 10.1007/BF00372059.

References
1.
Ito M . The innermost cell layer of the outer root sheath in anagen hair follicle: light and electron microscopic study. Arch Dermatol Res. 1986; 279(2):112-9. DOI: 10.1007/BF00417531. View

2.
Ito M . Electron microscopic study on cell differentiation in anagen hair follicles in mice. J Invest Dermatol. 1988; 90(1):65-72. DOI: 10.1111/1523-1747.ep12462569. View

3.
Reynolds E . The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol. 1963; 17:208-12. PMC: 2106263. DOI: 10.1083/jcb.17.1.208. View

4.
Pinkus H, Iwasaki T, Mishima Y . Outer root sheath keratinization in anagen and catagen of the mammalian hair follicle. A seventh distinct type of keratinization in the hair follicle: trichilemmal keratinization. J Anat. 1981; 133(Pt 1):19-35. PMC: 1167722. View

5.
Ito M, Tazawa T, Shimizu N, Ito K, Katsuumi K, Sato Y . Cell differentiation in human anagen hair and hair follicles studied with anti-hair keratin monoclonal antibodies. J Invest Dermatol. 1986; 86(5):563-9. DOI: 10.1111/1523-1747.ep12355183. View