Perspectives in the Application of Residual Dipolar Couplings in the Structure Elucidation of Weakly Aligned Small Molecules

Overview

Journal Magn Reson Chem

Specialty Chemistry

Date 2016 Oct 16

PMID 27743456

Citations 8

Authors

Volker Schmidts

Affiliations

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Abstract

This perspective article aims to review the general methodology in the application of residual dipolar couplings (RDCs) in the structure elucidation of small molecules and give the author's view on challenges for future applications. Recent improvements in the availability of alignment media, new pulse sequences for the measurement of couplings and improvements in the analysis software have garnered widespread interest in the technique. However, further generalization is needed in order to make RDC analysis into a truly "routine" method. Copyright © 2016 John Wiley & Sons, Ltd.

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