Does Intrauterine Saline Infusion by Intrauterine Insemination (IUI) Catheter As Endometrial Injury During IVF Cycles Improve Pregnancy Outcomes Among Patients with Recurrent Implantation Failure?: An RCT

Overview

Journal Int J Reprod Biomed

Specialty Reproductive Medicine

Date 2016 Oct 15

PMID 27738660

Citations 12

Authors

Saghar Salehpour

Marzieh Zamaniyan

Nasrin Saharkhiz

Shahrzad Zadeh Modares

Sedighe Hosieni

Samira Seif

Narges Malih

Parinaz Rezapoor

Mohammad-Reza Sohrabi

Affiliations

Soon will be listed here.

Abstract

Background: Recurrent implantation failure is one of the most issues in IVF cycles. Some researchers found that beneficial effects of endometrial Scratching in women with recurrent implantation failure, while some authors demonstrated contrary results.

Objective: The present study aimed to investigate the effect of intrauterine. Saline infusion as a form of endometrial injury, during fresh in vitro fertilization-embryo transfer cycle, among patients with recurrent implantation failure.

Materials And Methods: In this clinical trial study 63 women undergoing assisted reproductive technology were divided into two groups either local endometrial injury by intrauterine saline infusion during day 3-5 of the ongoing controlled ovarian stimulation cycle, or IVF protocol performed without any other intervention in Taleghani Hospital, Tehran, Iran. The main outcome measure was clinical pregnancy rates.

Results: Patients who received intra uterine saline infusion (n=20), had significantly lower clinical pregnancy numbers (1 vs. 9, p<0.05) and implantation rates (4.7% vs. 41.6%, p<0.05), compared to controls (n=39). However, there was no significant difference in miscarriage rates (9.4% vs. 8.7%, p>0.05) and multiple pregnancy numbers (1 vs. 3, p>0.05) between groups.

Conclusion: When intrauterine saline infusion as a form of endometrial injury is performed during the ongoing IVF cycles it has negative effect on reproductive outcomes among patients with recurrent implantation failure.

Citing Articles

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Effects of Autologous Platelet-Rich Plasma in women with repeated implantation failure undergoing assisted reproduction.

Bakhsh A, Maleki N, Sadeghi M, SadeghiTabar A, Tavakoli M, Zafardoust S JBRA Assist Reprod. 2021; 26(1):84-87.

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