Meagre Effects of Disuse on the Human Fibula Are Not Explained by Bone Size or Geometry

Overview

Journal Osteoporos Int

Specialties Endocrinology
Orthopedics

Date 2016 Oct 14

PMID 27734100

Citations 5

Authors

A Ireland

R F Capozza

G R Cointry

L Nocciolino

J L Ferretti

J Rittweger

Affiliations

Soon will be listed here.

Abstract

Introduction: The fibula supports only a small and highly variable proportion of shank compressive load (-8 to +19 %), and little is known about other kinds of stresses. Hence, whilst effects of habitual loading on tibia are well-known, fibula response to disuse is difficult to predict.

Methods: Therefore, we assessed fibular bone strength using peripheral quantitative computed tomography (pQCT) at 5 % increments from 5 to 90 % distal-proximal tibia length in nine participants with long-term spinal cord injury (SCI; age 39.2 ± 6.2 years, time since injury 17.8 ± 7.4 years), representing a cross-sectional model of long-term disuse and in nine able-bodied counterparts of similar age (39.6 ± 7.8 years), height and mass.

Results: There was no group difference in diaphyseal fibula total bone mineral content (BMC) (P = 0.22, 95 % CIs -7.4 % to -13.4 % and +10.9 % to +19.2 %). Site by group interactions (P < 0.001) revealed 27 and 22 % lower BMC in SCI at 5 and 90 % (epiphyseal) sites only. Cortical bone geometry differed at mid and distal diaphysis, with lower endocortical circumference and greater cortical thickness in SCI than able-bodied participants in this region only (interactions both P < 0.01). Tibia bone strength was also assessed; bone by group interactions showed smaller group differences in fibula than tibia for all bone parameters, with opposing effects on distal diaphysis geometry in the two bones (all Ps < 0.001).

Conclusions: These results suggest that the structure of the fibula diaphysis is not heavily influenced by compressive loading, and only mid and distal diaphysis are influenced by bending and/or torsional loads. The fibula is less influenced by disuse than the tibia, which cannot satisfactorily be explained by differences in bone geometry or relative changes in habitual loading in disuse. Biomechanical study of the shank loading environment may give new information pertaining to factors influencing bone mechanoadaptation.

Citing Articles

Simulation-based prediction of bone healing and treatment recommendations for lower leg fractures: Effects of motion, weight-bearing and fibular mechanics.

Orth M, Ganse B, Andres A, Wickert K, Warmerdam E, Muller M Front Bioeng Biotechnol. 2023; 11:1067845.

PMID: 36890916 PMC: 9986461. DOI: 10.3389/fbioe.2023.1067845.

Fibula response to disuse: a longitudinal analysis in people with spinal cord injury.

Abdelrahman S, Purcell M, Rantalainen T, Coupaud S, Ireland A Arch Osteoporos. 2022; 17(1):51.

PMID: 35305185 PMC: 8934326. DOI: 10.1007/s11657-022-01095-9.

Differences in the Cortical Structure of the Whole Fibula and Tibia Between Long-Distance Runners and Untrained Controls. Toward a Wider Conception of the Biomechanical Regulation of Cortical Bone Structure.

Luscher S, Nocciolino L, Pilot N, Pisani L, Ireland A, Rittweger J Front Endocrinol (Lausanne). 2019; 10:833.

PMID: 31827461 PMC: 6890608. DOI: 10.3389/fendo.2019.00833.

Fibula: The Forgotten Bone-May It Provide Some Insight On a Wider Scope for Bone Mechanostat Control?.

Rittweger J, Ireland A, Luscher S, Nocciolino L, Pilot N, Pisani L Curr Osteoporos Rep. 2018; 16(6):775-778.

PMID: 30393831 DOI: 10.1007/s11914-018-0497-x.

Mechanical basis of bone strength: influence of bone material, bone structure and muscle action.

Hart N, Nimphius S, Rantalainen T, Ireland A, Siafarikas A, Newton R J Musculoskelet Neuronal Interact. 2017; 17(3):114-139.

PMID: 28860414 PMC: 5601257.

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