Stability of Diazoxide in Extemporaneously Compounded Oral Suspensions

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2016 Oct 12

PMID 27727306

Citations 3

Authors

Mihaela Friciu

Sarra Zaraa

V Gaelle Roullin

Gregoire Leclair

Affiliations

Soon will be listed here.

Abstract

The objective of this study was to evaluate the stability of diazoxide in extemporaneously compounded oral suspensions. Oral suspensions of diazoxide 10 mg/mL were prepared from either bulk drug or capsules dispersed in either Oral Mix or Oral Mix Sugar Free. These suspensions were stored at 5°C and 25°C/60%RH in bottles and oral syringes for a total of 90 days. At predetermined time intervals, suspensions were inspected for homogeneity, color or odor change; the pH was measured and the concentration of diazoxide was evaluated by ultraviolet detection using a stability-indicating high pressure liquid chromatography method. All preparations were demonstrated to be chemically stable for at least 90 days.

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