Pattern Recognition Receptors in Zebrafish Provide Functional and Evolutionary Insight into Innate Immune Signaling Pathways

Overview

Journal Cell Mol Immunol

Date 2016 Oct 11

PMID 27721456

Citations 64

Authors

Yajuan Li

Yuelong Li

Xiaocong Cao

Xiangyu Jin

Tengchuan Jin

Affiliations

Soon will be listed here.

Abstract

Pattern recognition receptors (PRRs) and their signaling pathways have essential roles in recognizing various components of pathogens as well as damaged cells and triggering inflammatory responses that eliminate invading microorganisms and damaged cells. The zebrafish relies heavily on these primary defense mechanisms against pathogens. Here, we review the major PRR signaling pathways in the zebrafish innate immune system and compare these signaling pathways in zebrafish and humans to reveal their evolutionary relationship and better understand their innate immune defense mechanisms.

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