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» Articles » PMID: 277211

The Nitroimidazoles As Radiosensitizers and Cytotoxic Agents

Overview
Journal Br J Cancer Suppl
Specialty Oncology
Date 1978 Jun 1
PMID 277211
Citations 5
Authors
E J Hall
R Miller
M Astro
F Rini
Affiliations
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Abstract

Using hamster cells in culture, the radiosensitizing and cytotoxic properties of 8 electron-affinic drugs have been compared. These include nitrofurans derivatives as well as 2 and 5-nitroimidazoles. Most work has been performed with misonidazole for which it appears that, at 37 degree C, the concentration of drug required to produce a given level of cell killing is inversely proportional to the square of the exposure time. Misonidazole was also compared with X-rays for its ability to produce neoplastic transformations in vitro, using the C3H 10T 1/2 cell line.

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References
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