Surgical Outcomes for the Ruptured Hepatocellular Carcinoma: Multicenter Analysis with a Case-Controlled Study

Overview

Journal J Gastrointest Surg

Specialty Gastroenterology

Date 2016 Oct 9

PMID 27718151

Citations 17

Authors

Shogo Tanaka

Masaki Kaibori

Masaki Ueno

Hiroshi Wada

Fumitoshi Hirokawa

Takuya Nakai

Hiroya Iida

Hidetoshi Eguchi

Michihiro Hayashi

Shoji Kubo

Affiliations

Soon will be listed here.

Abstract

Background: While spontaneously ruptured hepatocellular carcinoma (HCC) has a poor prognosis, the true impact of a rupture on survival after hepatic resection is unclear.

Methods: Fifty-eight patients with ruptured HCC and 1922 with non-ruptured HCC underwent hepatic resection between 2000 and 2013. To correct the difference in the clinicopathological factors between the two groups, propensity score matching (PSM) was used at a 1:1 ratio, resulting in a comparison of 42 patients/group. We investigated outcomes in all patients with ruptured HCC and compared outcomes between the two matched groups.

Results: Of the 58 patients with ruptured HCC, 7 patients (13 %) died postoperatively. Overall survival (OS) rate at 5 years after hepatic resection was 37 %. Emergency hepatic resection was an independent risk factor for in-hospital death and Child-Pugh class B for unfavorable OS in multivariate analysis. Clinicopathological variables were well-balanced between the two groups after PSM. No significant differences were noted in incidence of in-hospital death (ruptured HCC 12 % vs non-ruptured HCC 2 %, p = 0.202) or OS rate (5/10-year; 42 %/38 % vs 67 %/30 %, p = 0.115).

Conclusion: Emergency hepatic resection should be avoided for ruptured HCC in Child-Pugh class B patients. Rupture itself was not a risk for unfavorable surgical outcomes.

Citing Articles

Long-term outcomes of ruptured hepatocellular carcinoma: international multicentre study.

Joliat G, de Man R, Rijckborst V, Cimino M, Torzilli G, Choi G Br J Surg. 2024; 111(4).

PMID: 38630792 PMC: 11023170. DOI: 10.1093/bjs/znae093.

Nomogram for Estimation of Acute Liver Failure Risk in Spontaneous Ruptured Hepatocellular Carcinoma.

Zhao Z, Jiang C, Wu Q, Lv G, Wang M J Hepatocell Carcinoma. 2023; 10:2223-2237.

PMID: 38107544 PMC: 10725690. DOI: 10.2147/JHC.S438346.

Meta-analysis of Prognostic Factors for Overall Survival Among Resected Patients with Spontaneous Ruptured Hepatocellular Carcinoma.

Lv T, Liu F, Jin Y, Hu H, Ma W, Li F J Gastrointest Surg. 2023; 27(12):2983-3000.

PMID: 37932594 DOI: 10.1007/s11605-023-05860-0.

Transarterial embolization followed by staged hepatectomy versus emergency hepatectomy for ruptured HCC: a meta-analysis.

Pan T, Gao F, Huang X, Xu X Clin Transl Oncol. 2023; 26(1):155-170.

PMID: 37328589 DOI: 10.1007/s12094-023-03232-3.

Prognosis of spontaneously ruptured hepatocellular carcinoma: a propensity score matching study.

Zhang S, Guo D, Zhang X, Fan J, Zhou J, Huang A J Cancer Res Clin Oncol. 2023; 149(11):8889-8896.

PMID: 37154926 DOI: 10.1007/s00432-023-04774-3.

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