Genetic and Epigenetic Components of Aspirin-Exacerbated Respiratory Disease

Overview

Journal Immunol Allergy Clin North Am

Specialty Allergy & Immunology

Date 2016 Oct 8

PMID 27712769

Citations 11

Authors

Amber Dahlin

Scott T Weiss

Affiliations

Soon will be listed here.

Abstract

Aspirin-exacerbated respiratory disease (AERD) severity and its clinical phenotypes are characterized by genetic variation within pathways for arachidonic acid metabolism, inflammation, and immune responses. Epigenetic effects, including DNA methylation and histone protein modification, contribute to regulation of many genes that contribute to inflammatory states in AERD. The development of noninvasive, predictive clinical tests using data from genetic, epigenetic, pharmacogenetic, and biomarker studies will improve precision medicine efforts for AERD and asthma treatment.

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References

Tantisira K, Lima J, Sylvia J, Klanderman B, Weiss S . 5-lipoxygenase pharmacogenetics in asthma: overlap with Cys-leukotriene receptor antagonist loci. Pharmacogenet Genomics. 2009; 19(3):244-7. PMC: 2731688. DOI: 10.1097/FPC.0b013e328326e0b1. View

Steinke J, Liu L, Huyett P, Negri J, Payne S, Borish L . Prominent role of IFN-γ in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2013; 132(4):856-65.e1-3. PMC: 3788084. DOI: 10.1016/j.jaci.2013.05.008. View

Baenkler H, Schafer D, Hosemann W . Eicosanoids from biopsy of normal and polypous nasal mucosa. Rhinology. 1996; 34(3):166-70. View

Chang H, Park J, Shin H, Park B, Shin H, Park C . Association analysis of FABP1 gene polymorphisms with aspirin-exacerbated respiratory disease in asthma. Exp Lung Res. 2014; 40(10):485-94. DOI: 10.3109/01902148.2014.927939. View

Laidlaw T, Boyce J . Pathogenesis of aspirin-exacerbated respiratory disease and reactions. Immunol Allergy Clin North Am. 2013; 33(2):195-210. PMC: 3781366. DOI: 10.1016/j.iac.2012.11.006. View

Kim S, Choi H, Yoon M, Ye Y, Park H . Dipeptidyl-peptidase 10 as a genetic biomarker for the aspirin-exacerbated respiratory disease phenotype. Ann Allergy Asthma Immunol. 2015; 114(3):208-13. DOI: 10.1016/j.anai.2014.12.003. View

Adamjee J, Suh Y, Park H, Choi J, Penrose J, Lam B . Expression of 5-lipoxygenase and cyclooxygenase pathway enzymes in nasal polyps of patients with aspirin-intolerant asthma. J Pathol. 2006; 209(3):392-9. DOI: 10.1002/path.1979. View

Berges-Gimeno M, Simon R, Stevenson D . The effect of leukotriene-modifier drugs on aspirin-induced asthma and rhinitis reactions. Clin Exp Allergy. 2002; 32(10):1491-6. DOI: 10.1046/j.1365-2745.2002.01501.x. View

Sharma J, Mohammed L . The role of leukotrienes in the pathophysiology of inflammatory disorders: is there a case for revisiting leukotrienes as therapeutic targets?. Inflammopharmacology. 2006; 14(1-2):10-6. DOI: 10.1007/s10787-006-1496-6. View

10.

Kim S, Cho B, Choi H, Shin E, Ye Y, Lee J . The SNP rs3128965 of HLA-DPB1 as a genetic marker of the AERD phenotype. PLoS One. 2014; 9(12):e111220. PMC: 4275175. DOI: 10.1371/journal.pone.0111220. View

11.

Yoshimura T, Yoshikawa M, Otori N, Haruna S, Moriyama H . Correlation between the prostaglandin D(2)/E(2) ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthma. Allergol Int. 2008; 57(4):429-36. DOI: 10.2332/allergolint.o-08-545. View

12.

Pascual M, Suzuki M, Isidoro-Garcia M, Padron J, Turner T, Lorente F . Epigenetic changes in B lymphocytes associated with house dust mite allergic asthma. Epigenetics. 2011; 6(9):1131-7. DOI: 10.4161/epi.6.9.16061. View

13.

Kasper L, Sladek K, Duplaga M, Bochenek G, Liebhart J, Gladysz U . Prevalence of asthma with aspirin hypersensitivity in the adult population of Poland. Allergy. 2003; 58(10):1064-6. DOI: 10.1034/j.1398-9995.2003.00267.x. View

14.

Kim S, Choi J, Holloway J, Suh C, Nahm D, Ha E . Leukotriene-related gene polymorphisms in patients with aspirin-intolerant urticaria and aspirin-intolerant asthma: differing contributions of ALOX5 polymorphism in Korean population. J Korean Med Sci. 2005; 20(6):926-31. PMC: 2779320. DOI: 10.3346/jkms.2005.20.6.926. View

15.

Cheong H, Park S, Kim M, Park J, Lee J, Byun J . Genome-wide methylation profile of nasal polyps: relation to aspirin hypersensitivity in asthmatics. Allergy. 2010; 66(5):637-44. DOI: 10.1111/j.1398-9995.2010.02514.x. View

16.

Drazen J, Yandava C, Dube L, Szczerback N, Hippensteel R, Pillari A . Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nat Genet. 1999; 22(2):168-70. DOI: 10.1038/9680. View

17.

Shin S, Park J, Kim Y, Uh S, Choi B, Kim M . A highly sensitive and specific genetic marker to diagnose aspirin-exacerbated respiratory disease using a genome-wide association study. DNA Cell Biol. 2012; 31(11):1604-9. DOI: 10.1089/dna.2012.1688. View

18.

Akahoshi M, Obara K, Hirota T, Matsuda A, Hasegawa K, Takahashi N . Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma. Hum Genet. 2005; 117(1):16-26. DOI: 10.1007/s00439-005-1285-0. View

19.

Bertorelli G, Bocchino V, Zhuo X, Chetta A, Del Donno M, Foresi A . Heat shock protein 70 upregulation is related to HLA-DR expression in bronchial asthma. Effects of inhaled glucocorticoids. Clin Exp Allergy. 1998; 28(5):551-60. DOI: 10.1046/j.1365-2222.1998.00251.x. View

20.

Louten J, Boniface K, De Waal Malefyt R . Development and function of TH17 cells in health and disease. J Allergy Clin Immunol. 2009; 123(5):1004-11. DOI: 10.1016/j.jaci.2009.04.003. View