Eosinophils and Mast Cells in Aspirin-Exacerbated Respiratory Disease

Overview

Journal Immunol Allergy Clin North Am

Specialty Allergy & Immunology

Date 2016 Oct 8

PMID 27712766

Citations 14

Authors

John W Steinke

Spencer C Payne

Larry Borish

Affiliations

Soon will be listed here.

Abstract

Aspirin-exacerbated respiratory disease (AERD) involves overexpression of proinflammatory mediators, including 5-lipoxygenase and leukotriene C synthase (LTCS), resulting in constitutive overproduction of cysteinyl leukotrienes. Mast cells and eosinophils have roles in mediating many of the observed effects. Increased levels of both interleukin-4 (IL-4) and interferon (IFN)-γ are present in the tissue of patients with AERD. Previous studies showed that IL-4 is primarily responsible for the upregulation of LTCS by mast cells. Our studies show that IFN-γ, but not IL-4, drives this process in eosinophils. This article examines the overall role that eosinophils and mast cells contribute to the pathophysiology of AERD.

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