Zika: the Origin and Spread of a Mosquito-borne Virus

Overview

Journal Bull World Health Organ

Specialty Public Health

Date 2016 Oct 7

PMID 27708473

Citations 207

Authors

Mary Kay Kindhauser

Tomas Allen

Veronika Frank

Ravi Shankar Santhana

Christopher Dye

Affiliations

Soon will be listed here.

Abstract

Objective: To describe the temporal and geographical distribution of Zika virus infection and associated neurological disorders, from 1947 to 1 February 2016, when Zika became a Public Health Emergency of International Concern (PHEIC).

Methods: We did a literature search using the terms "Zika" and "ZIKV" in PubMed, cross-checked the findings for completeness against other published reviews and added formal notifications to WHO submitted under the International Health Regulations.

Findings: From the discovery of Zika virus in Uganda in 1947 to the declaration of a PHEIC by the World Health Organization (WHO) on 1 February 2016, a total of 74 countries and territories had reported human Zika virus infections. The timeline in this paper charts the discovery of the virus (1947), its isolation from mosquitos (1948), the first human infection (1952), the initial spread of infection from Asia to a Pacific island (2007), the first known instance of sexual transmission (2008), reports of Guillain-Barré syndrome (2014) and microcephaly (2015) linked to Zika infections and the first appearance of Zika in the Americas (from 2015).

Conclusion: Zika virus infection in humans appears to have changed in character as its geographical range has expanded from equatorial Africa and Asia. The change is from an endemic, mosquito-borne infection causing mild illness to one that can cause large outbreaks linked with neurological sequelae and congenital abnormalities.

Citing Articles

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References

HAMMON W, SCHRACK Jr W, SATHER G . Serological survey for a arthropod-borne virus infections in the Philippines. Am J Trop Med Hyg. 1958; 7(3):323-8. DOI: 10.4269/ajtmh.1958.7.323. View

Monlun E, Zeller H, Le Guenno B, Traore-Lamizana M, Hervy J, Adam F . [Surveillance of the circulation of arbovirus of medical interest in the region of eastern Senegal]. Bull Soc Pathol Exot. 1993; 86(1):21-8. View

Enserink M . INFECTIOUS DISEASES. An obscure mosquito-borne disease goes global. Science. 2015; 350(6264):1012-3. DOI: 10.1126/science.350.6264.1012. View

DICK G, KITCHEN S, HADDOW A . Zika virus. I. Isolations and serological specificity. Trans R Soc Trop Med Hyg. 1952; 46(5):509-20. DOI: 10.1016/0035-9203(52)90042-4. View

Macnamara F, Horn D, PORTERFIELD J . Yellow fever and other arthropod-borne viruses; a consideration of two serological surveys made in South Western Nigeria. Trans R Soc Trop Med Hyg. 1959; 53(2):202-12. DOI: 10.1016/0035-9203(59)90072-0. View

Henderson B, Kirya G, HEWITT L . Serological survey for arboviruses in Uganda, 1967-69. Bull World Health Organ. 1970; 42(5):797-805. PMC: 2427494. View

Renaudet J, Jan C, RIDET J, Adam C, Robin Y . [A serological survey of arboviruses in the human population of Senegal]. Bull Soc Pathol Exot Filiales. 1978; 71(2):131-40. View

Filipe A, de Carvalho R, Relvas A, Casaca V . Arbovirus studies in Angola: Serological survey for antibodies to arboviruses. Am J Trop Med Hyg. 1975; 24(3):516-20. DOI: 10.4269/ajtmh.1975.24.516. View

Cao-Lormeau V, Roche C, Teissier A, Robin E, Berry A, Mallet H . Zika virus, French polynesia, South pacific, 2013. Emerg Infect Dis. 2014; 20(6):1085-6. PMC: 4036769. DOI: 10.3201/eid2006.140138. View

10.

Fagbami A, Monath T, Fabiyi A . Dengue virus infections in Nigeria: a survey for antibodies in monkeys and humans. Trans R Soc Trop Med Hyg. 1977; 71(1):60-5. DOI: 10.1016/0035-9203(77)90210-3. View

11.

POND W . ARTHROPOD-BORNE VIRUS ANTIBODIES IN SERA FROM RESIDENTS OF SOUTH-EAST ASIA. Trans R Soc Trop Med Hyg. 1963; 57:364-71. DOI: 10.1016/0035-9203(63)90100-7. View

12.

Moore D, CAUSEY O, Carey D, Reddy S, Cooke A, Akinkugbe F . Arthropod-borne viral infections of man in Nigeria, 1964-1970. Ann Trop Med Parasitol. 1975; 69(1):49-64. DOI: 10.1080/00034983.1975.11686983. View

13.

Musso D, Nhan T, Robin E, Roche C, Bierlaire D, Zisou K . Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014. Euro Surveill. 2014; 19(14). DOI: 10.2807/1560-7917.es2014.19.14.20761. View

14.

Musso D, Gubler D . Zika Virus. Clin Microbiol Rev. 2016; 29(3):487-524. PMC: 4861986. DOI: 10.1128/CMR.00072-15. View

15.

Oehler E, Watrin L, Larre P, Leparc-Goffart I, Lastere S, Valour F . Zika virus infection complicated by Guillain-Barre syndrome--case report, French Polynesia, December 2013. Euro Surveill. 2014; 19(9). DOI: 10.2807/1560-7917.es2014.19.9.20720. View

16.

DICK G . Zika virus. II. Pathogenicity and physical properties. Trans R Soc Trop Med Hyg. 1952; 46(5):521-34. DOI: 10.1016/0035-9203(52)90043-6. View

17.

Dupont-Rouzeyrol M, OConnor O, Calvez E, Daures M, John M, Grangeon J . Co-infection with Zika and dengue viruses in 2 patients, New Caledonia, 2014. Emerg Infect Dis. 2015; 21(2):381-2. PMC: 4313662. DOI: 10.3201/eid2102.141553. View

18.

Henderson B, METSELAAR D, Cahill K, TIMMS G, Tukei P, Williams M . Yellow fever immunity surveys in northern Uganda and Kenya and eastern Somalia, 1966-67. Bull World Health Organ. 1968; 38(2):229-37. PMC: 2554316. View

19.

Tognarelli J, Ulloa S, Villagra E, Lagos J, Aguayo C, Fasce R . A report on the outbreak of Zika virus on Easter Island, South Pacific, 2014. Arch Virol. 2015; 161(3):665-8. DOI: 10.1007/s00705-015-2695-5. View

20.

Korhonen E, Huhtamo E, Smura T, Kallio-Kokko H, Raassina M, Vapalahti O . Zika virus infection in a traveller returning from the Maldives, June 2015. Euro Surveill. 2016; 21(2). DOI: 10.2807/1560-7917.ES.2016.21.2.30107. View