Visualizing the Architectures and Interactions of Nuclear Receptors

Overview

Journal Endocrinology

Publisher Oxford University Press

Specialty Endocrinology

Date 2016 Oct 6

PMID 27704949

Citations 22

Authors

Sepideh Khorasanizadeh

Fraydoon Rastinejad

Affiliations

Soon will be listed here.

Abstract

Nuclear receptors (NRs) are master regulators of broad genetic programs in metazoans. These programs are regulated in part by the small-molecule ligands that bind NRs and modulate their interactions with transcriptional coregulatory factors. X-ray crystallography is now delivering more complete pictures of how the multidomain architectures of NR homo- and heterodimers are physically arranged on their DNA elements and how ligands and coactivator peptides act through these complexes. Complementary studies are also pointing to a variety of novel mechanisms by which NRs access their DNA-response elements within chromatin. Here, we review the new structural advances together with proteomic discoveries that shape our understanding of how NRs form a variety of functional interactions with collaborating factors in chromatin.

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