Expression of Cyclooxygenase-2 in Cervical Cancer is Associated with Lymphovascular Invasion

Overview

Journal Oncol Lett

Specialty Oncology

Date 2016 Oct 5

PMID 27698799

Citations 8

Authors

Friederike Hoellen

Annika Waldmann

Constanze Banz-Jansen

Achim Rody

Maria Heide

Frank Koster

Julika Ribbat-Idel

Christoph Thorns

Maximilian Gebhard

Martina Oberlander

Jens K Habermann

Marc Thill

Affiliations

Soon will be listed here.

Abstract

Cyclooxygenase-2 (COX-2) is associated with carcinogenesis and tumor progression. The current study analyzed the effect of COX-2 expression in patients with invasive squamous cervical cancer. Tissue samples from 123 cervical cancer patients were collected for a retrospective analysis using immunohistochemistry (IHC) with an antibody against COX-2. The clinical and survival data of the patients were analyzed. Positive staining for COX-2 (defined as an immunoreactivity score of ≥4) was detected in 28 patients (23%), with significantly higher percentages of staining in tumor cells compared with peritumoral stroma cells (P<0.001). COX-2 expression was significantly associated with lymphovascular space invasion (LVSI; P=0.017). The association of COX-2 expression with LVSI suggests a possible effect of COX-2 on tumor progression in cervical cancer. Further studies including larger patient collectives are required in order to perform analyses of clinical subgroups and patient survival.

Citing Articles

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