Alcohol-associated Cancer and Deregulation of Pol III Genes

Overview

Journal Gene

Specialty Molecular Biology

Date 2016 Oct 5

PMID 27697617

Citations 13

Authors

Ganggang Shi

Shuping Zhong

Affiliations

Soon will be listed here.

Abstract

Emerging evidence indicates that alcohol intake is associated with human cancers in different organs. However, the molecular mechanism of alcohol-associated human cancers remains to be elucidated. Here, this paper aimed to clarify a novel mechanism of alcohol-promoted cell transformation and tumor development. Alcohol induces JNK1 activation and increases cellular levels of c-Jun to upregulate Brf1 expression and Pol III gene transcription, leading to an enhancement of rates of cell transformation and tumor formation.

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