Probing and Rearranging the Transcription Factor Network Controlling the Endoderm

Overview

Journal Worm

Date 2016 Oct 4

PMID 27695655

Citations 3

Authors

Tobias Wiesenfahrt

Erin Osborne Nishimura

Janette Y Berg

James D McGhee

Affiliations

Soon will be listed here.

Abstract

The ELT-2 GATA factor is the predominant transcription factor regulating gene expression in the intestine, following endoderm specification. We comment on our previous study (Wiesenfahrt ., 2016) that investigated how the gene is controlled by END-1, END-3 and ELT-7, the 3 endoderm specific GATA factors that lie upstream in the regulatory hierarchy. We also discuss the unexpected result that ELT-2, if expressed sufficiently early and at sufficiently high levels, can specify the endoderm, replacing the normal functions of END-1 and END-3.

Citing Articles

Evolutionary Change in Gut Specification in Centers on the GATA Factor ELT-3 in an Example of Developmental System Drift.

Broitman-Maduro G, Maduro M J Dev Biol. 2023; 11(3).

PMID: 37489333 PMC: 10366740. DOI: 10.3390/jdb11030032.

Evolution and Developmental System Drift in the Endoderm Gene Regulatory Network of and Other Nematodes.

Ewe C, Torres Cleuren Y, Rothman J Front Cell Dev Biol. 2020; 8:170.

PMID: 32258041 PMC: 7093329. DOI: 10.3389/fcell.2020.00170.

Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network.

Torres Cleuren Y, Ewe C, Chipman K, Mears E, Wood C, Al-Alami C Elife. 2019; 8.

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