Clinical Significance and Prognostic Value of TRIM24 Expression in Esophageal Squamous Cell Carcinoma

Overview

Journal Aging (Albany NY)

Specialty Geriatrics

Date 2016 Oct 1

PMID 27689360

Citations 6

Authors

Jun Chi

Qing Yang

Xiao-Feng Xie

Xian-Zi Yang

Mei-Yin Zhang

Hui-Yun Wang

Guo-Liang Xu

Affiliations

Soon will be listed here.

Abstract

Tripartite motif-containing 24 (TRIM24), a member of the transcription intermediary factor 1 family, is defined as a co-regulator with several nuclear receptors, such as RARα. TRIM24 has been reported to be involved in many cancers. In this study, we aimed to investigate the expression pattern and prognostic significance of TRIM24 and its relationship with RARα in esophageal squamous cell cancer (ESCC). Both mRNA and protein expression levels of TRIM24 were found to be significantly decreased in ESCC, as judged by qRT-PCR and western blot. Immunohistochemistry staining shows that the reduced TRIM24 protein is associated with lymph node metastasis (=0.024), advance pathological TNM (pTNM) stage (=0.046) and recurrence/metastasis (=0.001). Upregulated TRIM24 protein predicts longer overall survival and disease-free survival (both <0.001) and is an independent predictor for good prognosis (HR, 0.519; 95%CI, 0.341-0.788; =0.002). TRIM24 expression has been proven remarkably to improve prediction of survival of pTNM stage in ESCC patients, especially in stage I and II. However, no significant relationship was found between TRIM24 and RARα expression levels. In conclusion, reduced TRIM24 protein is associated with poor survival in ESCC patients, suggesting TRIM24 protein is a potential prognostic biomarker for ESCC.

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References

Chambon M, Orsetti B, Berthe M, Bascoul-Mollevi C, Rodriguez C, Duong V . Prognostic significance of TRIM24/TIF-1α gene expression in breast cancer. Am J Pathol. 2011; 178(4):1461-9. PMC: 3128458. DOI: 10.1016/j.ajpath.2010.12.026. View

Khetchoumian K, Teletin M, Tisserand J, Mark M, Herquel B, Ignat M . Loss of Trim24 (Tif1alpha) gene function confers oncogenic activity to retinoic acid receptor alpha. Nat Genet. 2007; 39(12):1500-6. DOI: 10.1038/ng.2007.15. View

Chakravarti N, Mathur M, Bahadur S, Shukla N, Ralhan R . Retinoic acid receptor-alpha as a prognostic indicator in oral squamous cell carcinoma. Int J Cancer. 2002; 103(4):544-9. DOI: 10.1002/ijc.10819. View

Heery D, Kalkhoven E, Hoare S, Parker M . A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature. 1997; 387(6634):733-6. DOI: 10.1038/42750. View

Kumar A, Kaur J, Chattopadhyay T, Mathur M, Ralhan R . Differential expression of retinoic acid receptors in normal and malignant esophageal tissues. J Exp Ther Oncol. 2004; 4(1):1-8. View

Fujishima F, Suzuki T, Nakamura Y, Taniyama Y, Ono K, Sugawara A . Retinoid receptors in human esophageal squamous cell carcinoma: retinoid X receptor as a potent prognostic factor. Pathol Int. 2011; 61(7):401-8. DOI: 10.1111/j.1440-1827.2011.02674.x. View

Hu K, Chen F, Ge J, Cao L, Li H . Retinoid receptors in gastric cancer: expression and influence on prognosis. Asian Pac J Cancer Prev. 2012; 13(5):1809-17. DOI: 10.7314/apjcp.2012.13.5.1809. View

Zhang W, Rashid A, Wu H, Xu X . Differential expression of retinoic acid receptors and p53 protein in normal, premalignant, and malignant esophageal tissues. J Cancer Res Clin Oncol. 2001; 127(4):237-42. DOI: 10.1007/s004320000183. View

Chakravarti N, Lotan R, Diwan A, Warneke C, Johnson M, Prieto V . Decreased expression of retinoid receptors in melanoma: entailment in tumorigenesis and prognosis. Clin Cancer Res. 2007; 13(16):4817-24. DOI: 10.1158/1078-0432.CCR-06-3026. View

10.

Meroni G, Diez-Roux G . TRIM/RBCC, a novel class of 'single protein RING finger' E3 ubiquitin ligases. Bioessays. 2005; 27(11):1147-57. DOI: 10.1002/bies.20304. View

11.

Gudas L, Wagner J . Retinoids regulate stem cell differentiation. J Cell Physiol. 2010; 226(2):322-30. PMC: 3315372. DOI: 10.1002/jcp.22417. View

12.

Miki T, Fleming T, Crescenzi M, Molloy C, Blam S, Reynolds S . Development of a highly efficient expression cDNA cloning system: application to oncogene isolation. Proc Natl Acad Sci U S A. 1991; 88(12):5167-71. PMC: 51833. DOI: 10.1073/pnas.88.12.5167. View

13.

Herquel B, Ouararhni K, Khetchoumian K, Ignat M, Teletin M, Mark M . Transcription cofactors TRIM24, TRIM28, and TRIM33 associate to form regulatory complexes that suppress murine hepatocellular carcinoma. Proc Natl Acad Sci U S A. 2011; 108(20):8212-7. PMC: 3100982. DOI: 10.1073/pnas.1101544108. View

14.

Hatakeyama S . TRIM proteins and cancer. Nat Rev Cancer. 2011; 11(11):792-804. DOI: 10.1038/nrc3139. View

15.

Allton K, Jain A, Herz H, Tsai W, Jung S, Qin J . Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A. 2009; 106(28):11612-6. PMC: 2710642. DOI: 10.1073/pnas.0813177106. View

16.

Findlay J, Middleton M, Tomlinson I . A systematic review and meta-analysis of somatic and germline DNA sequence biomarkers of esophageal cancer survival, therapy response and stage. Ann Oncol. 2014; 26(4):624-644. PMC: 4374384. DOI: 10.1093/annonc/mdu449. View

17.

Yang Q, Luo G, Li Y, Shan H, Wang H, Xu G . Expression of Rac-1 related to tumor depth, lymph node metastasis and patient prognosis in esophageal squamous cell carcinoma. Med Oncol. 2013; 30(4):689. DOI: 10.1007/s12032-013-0689-2. View

18.

Chen W, Zheng R, Baade P, Zhang S, Zeng H, Bray F . Cancer statistics in China, 2015. CA Cancer J Clin. 2016; 66(2):115-32. DOI: 10.3322/caac.21338. View

19.

Tsai W, Wang Z, Yiu T, Akdemir K, Xia W, Winter S . TRIM24 links a non-canonical histone signature to breast cancer. Nature. 2010; 468(7326):927-32. PMC: 3058826. DOI: 10.1038/nature09542. View

20.

Cui Z, Cao W, Li J, Song X, Mao L, Chen W . TRIM24 overexpression is common in locally advanced head and neck squamous cell carcinoma and correlates with aggressive malignant phenotypes. PLoS One. 2013; 8(5):e63887. PMC: 3661592. DOI: 10.1371/journal.pone.0063887. View