Correlation Between Serum Leptin and Bone Mineral Density in Hemodialysis Patients

Overview

Journal J Renal Inj Prev

Specialty Nephrology

Date 2016 Oct 1

PMID 27689105

Citations 4

Authors

Mahin Ghorban-Sabbagh

Fatemeh Nazemian

Massih Naghibi

Mohammad-Taghi Shakeri

Saeedeh Ahmadi-Simab

Reza Javidi-Dasht-Bayaz

Affiliations

Soon will be listed here.

Abstract

Introduction: For diagnosing of specific types of bone lesions in hemodialysis (HD) patients, it is necessary to conduct a bone biopsy as the gold standard method. However, it is an invasive procedure. While different markers have been suggested as alternative methods, none of them has been selected. The frequency of hip fractures is 80 fold in HD patients who have two-fold mortality as compared with general population.

Objectives: Recently, serum leptin has been suggested as a bone density marker. This study tries to confirm this proposal.

Patients And Methods: In this study about 104 HD patients (53.8% male and 46.2% female) were enrolled. The average age was 38.28±7.89 years. Serum leptin, bone alkaline phosphatase, intact parathyroid hormone (iPTH), 25(OH)D, calcium, phosphorus and bone mineral density (BMD) (at the femoral neck and lumbar spine, as measured by dual-energy x-ray absorptiometry [DXA]) were assessed.

Results: Analysis by polynomial regression revealed no correlation between BMD Z-score at two points and serum leptin level. According to the thresholds of 25 ng/mL and 18-24 ng/mL in some studies, we detected 25 ng/mL as the threshold in our patients. Under this threshold, the leptin effect on bone mass was negative, and above the threshold of 25 ng/mL, we found leptin had positive effect on bone mass.

Conclusion: In this investigation, we found, leptin has a bimodal effect on bone mass. Cortical bones assessment may be a better option for assessment.

Citing Articles

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Update on the Crosstalk Between Adipose Tissue and Mineral Balance in General Population and Chronic Kidney Disease.

Karava V, Christoforidis A, Kondou A, Dotis J, Printza N Front Pediatr. 2021; 9:696942.

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The intriguing connections of leptin to hyperparathyroidism.

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