The Oral Cavity State in Renal Transplant Recipients

Overview

Journal Acta Stomatol Croat

Specialty Dentistry

Date 2016 Oct 1

PMID 27688404

Citations 5

Authors

Marija Gaspar

Ana Glavina

Kristina Grubisic

Ivan Sabol

Mirela Busic

Marinka Mravak

Affiliations

Soon will be listed here.

Abstract

Aim: Patients with a solid organ transplant can have many different complications in the mouth, as a result of immunosuppression and side effects of drugs. The aim of this study was to examine the frequency and type of oral lesions in renal transplant patients, dental status, oral hygiene, oral lesions related to drugs which patients take and the time of transplantation as well as the frequency of patient's visits to the dentist in the post-transplant period.

Material And Methods: The study was performed in a period of two years and included 100 subjects with a renal transplant during their regular control visits to the Department of Nephrology and Dialysis, Clinical Hospital Centre Zagreb and the Department of Oral Medicine, School of Dental Medicine, University of Zagreb and 100 randomly selected control subjects at the Department of Endodontics and Restorative Dentistry, School of Dental Medicine, University of Zagreb.

Results: Results showed a significantly higher incidence of oral lesions in patients with renal transplant (31%) compared to control subjects. The most frequent were erythematous (inflammatory changes), keratotic lesions and gingival hyperplasia. The average DMFT index was significantly lower in patients with renal transplant than in the control group. One third of patients had a subjective feeling of dry mouth. Oral hygiene was poor overall, and only a small number of subjects used the additional sustainers for oral hygiene. Most patients did not visit the dentist after the transplantation.

Conclusion: Renal transplant patients need a comprehensive and regular dental care during the pre- and post-transplant period and a doctor of dental medicine should be part of a multidisciplinary team of medical specialists.

Citing Articles

Assessment of Reliability of Three Indices Measuring Gingival Overgrowth.

Safa Alkateb A, Ozturk Ozener H, Kuru L Acta Stomatol Croat. 2023; 57(2):98-112.

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The Impact of Human Microbiotas in Hematopoietic Stem Cell and Organ Transplantation.

Sen T, Thummer R Front Immunol. 2022; 13:932228.

PMID: 35874759 PMC: 9300833. DOI: 10.3389/fimmu.2022.932228.

Comparative Analysis of Web of Science and Pubmed Indexed Medical Journals Published in Former Yugoslav Countries.

Masic I, Jankovic S Med Arch. 2020; 74(4):252-264.

PMID: 33041441 PMC: 7520058. DOI: 10.5455/medarh.2020.74.252-264.

Oral health complications after a heart transplant: a review.

Gruter M, Brand H Br Dent J. 2020; 228(3):177-182.

PMID: 32060460 DOI: 10.1038/s41415-020-1244-0.

Oral health status of adult heart transplant recipients in China: A cross-sectional study.

Cao Y, Chen X, Jia Y, Lv Y, Sun Z Medicine (Baltimore). 2018; 97(38):e12508.

PMID: 30235763 PMC: 6160112. DOI: 10.1097/MD.0000000000012508.

References

Khocht A, Schneider L . Periodontal management of gingival overgrowth in the heart transplant patient: a case report. J Periodontol. 1998; 68(11):1140-6. DOI: 10.1902/jop.1997.68.11.1140. View

James J, Marley J, Jamal S, Campbell B, Short C, Johnson R . The calcium channel blocker used with cyclosporin has an effect on gingival overgrowth. J Clin Periodontol. 2000; 27(2):109-15. DOI: 10.1034/j.1600-051x.2000.027002109.x. View

Petti S, Polimeni A, Berloco P, Scully C . Orofacial diseases in solid organ and hematopoietic stem cell transplant recipients. Oral Dis. 2012; 19(1):18-36. DOI: 10.1111/j.1601-0825.2012.01925.x. View

de Oliveira Costa F, Ferreira S, Cota L, da Costa J, Aguiar M . Prevalence, severity, and risk variables associated with gingival overgrowth in renal transplant subjects treated under tacrolimus or cyclosporin regimens. J Periodontol. 2006; 77(6):969-75. DOI: 10.1902/jop.2006.050327. View

Lopez-Pintor R, Hernandez G, de Arriba L, De Andres A . Comparison of oral lesion prevalence in renal transplant patients under immunosuppressive therapy and healthy controls. Oral Dis. 2009; 16(1):89-95. DOI: 10.1111/j.1601-0825.2009.01609.x. View

King G, Healy C, Glover M, Kwan J, Williams D, Leigh I . Prevalence and risk factors associated with leukoplakia, hairy leukoplakia, erythematous candidiasis, and gingival hyperplasia in renal transplant recipients. Oral Surg Oral Med Oral Pathol. 1994; 78(6):718-26. DOI: 10.1016/0030-4220(94)90086-8. View

Tyrzyk S, Sadlak-Nowicka J, Kedzia A, Bochniak M, Szumska-Tyrzyk B, Rutkowski P . [Clinical and mycological examinations of oral mucosa in cyclosporine A treated patients after renal transplantation]. Przegl Lek. 2004; 61(5):467-72. View

Rojas G, Bravo L, Cordero K, Sepulveda L, Elgueta L, Diaz J . Integrity of the oral tissues in patients with solid-organ transplants. J Transplant. 2012; 2012:603769. PMC: 3272846. DOI: 10.1155/2012/603769. View

Sahebjamee M, Shahabi M, Nikoobakht M, Momen Beitollahi J, Mansourian A . Oral lesions in kidney transplant patients. Iran J Kidney Dis. 2010; 4(3):232-6. View

10.

Geddes C, Church C, Collidge T, McCruden E, Gillespie G, Matthews E . Management of cytomegalovirus infection by weekly surveillance after renal transplant: analysis of cost, rejection and renal function. Nephrol Dial Transplant. 2003; 18(9):1891-8. DOI: 10.1093/ndt/gfg283. View

11.

Murphy O, Gould F . Prevention of nosocomial infection in solid organ transplantation. J Hosp Infect. 1999; 42(3):177-83. DOI: 10.1053/jhin.1999.0599. View

12.

Olczak-Kowalczyk D, Pawlowska J, Garczewska B, Smirska E, Grenda R, Syczewska M . Oral candidiasis in immunosuppressed children and young adults after liver or kidney transplantation. Pediatr Dent. 2010; 32(3):189-94. View

13.

Lopez-Pintor R, Hernandez G, de Arriba L, de Andres A . Lip cancer in renal transplant patients. Oral Oncol. 2010; 47(1):68-71. DOI: 10.1016/j.oraloncology.2010.10.017. View

14.

Rose B, Wilkins D, Li W, Tran N, Thompson C, Cossart Y . Human papillomavirus in the oral cavity of patients with and without renal transplantation. Transplantation. 2006; 82(4):570-3. DOI: 10.1097/01.tp.0000231706.79165.e5. View

15.

Pernu H, Pernu L, Huttunen K, Nieminen P, Knuuttila M . Gingival overgrowth among renal transplant recipients related to immunosuppressive medication and possible local background factors. J Periodontol. 1992; 63(6):548-53. DOI: 10.1902/jop.1992.63.6.548. View

16.

Kramer I, PINDBORG J, Bezroukov V, Infirri J . Guide to epidemiology and diagnosis of oral mucosal diseases and conditions. World Health Organization. Community Dent Oral Epidemiol. 1980; 8(1):1-26. DOI: 10.1111/j.1600-0528.1980.tb01249.x. View

17.

Dirschnabel A, Martins A, Dantas S, de Oliveira Ribas M, Gregio A, Alanis L . Clinical oral findings in dialysis and kidney-transplant patients. Quintessence Int. 2011; 42(2):127-33. View

18.

Saalman R, Sundell S, Kullberg-Lindh C, Lovsund-Johannesson E, Jontell M . Long-standing oral mucosal lesions in solid organ-transplanted children-a novel clinical entity. Transplantation. 2010; 89(5):606-11. DOI: 10.1097/TP.0b013e3181ca7b04. View

19.

Goldman K . Dental management of patients with bone marrow and solid organ transplantation. Dent Clin North Am. 2006; 50(4):659-76, viii. DOI: 10.1016/j.cden.2006.06.009. View

20.

Al-Mohaya M, Darwazeh A, Bin-Salih S, Al-Khudair W . Oral lesions in Saudi renal transplant patients. Saudi J Kidney Dis Transpl. 2008; 20(1):20-9. View