Molecular Imaging of Angiogenesis in Cardiac Regeneration

Overview

Journal Curr Cardiovasc Imaging Rep

Publisher Springer

Specialty Cardiology & Vascular Diseases

Date 2016 Sep 30

PMID 27683600

Citations 15

Authors

Ljubica Mandic

Denise Traxler

Alfred Gugerell

Katrin Zlabinger

Dominika Lukovic

Noemi Pavo

Georg Goliasch

Andreas Spannbauer

Johannes Winkler

Mariann Gyongyosi

Affiliations

Soon will be listed here.

Abstract

Purpose Of Review: Myocardial infarction (MI) leading to heart failure displays an important cause of death worldwide. Adequate restoration of blood flow to prevent this transition is a crucial factor to improve long-term morbidity and mortality. Novel regenerative therapies have been thoroughly investigated within the past decades.

Recent Findings: Increased angiogenesis in infarcted myocardium has shown beneficial effects on the prognosis of MI; therefore, the proangiogenic capacity of currently tested treatments is of specific interest. Molecular imaging to visualize formation of new blood vessels in vivo displays a promising option to monitor proangiogenic effects of regenerative substances.

Summary: Based on encouraging results in preclinical models, molecular angiogenesis imaging has recently been applied in a small set of patients. This article reviews recent literature on noninvasive in vivo molecular imaging of angiogenesis after MI as an integral part of cardiac regeneration.

Citing Articles

Increased [F]FDG uptake in the infarcted myocardial area displayed by combined PET/CMR correlates with snRNA-seq-detected inflammatory cell invasion.

Lukovic D, Gyongyosi M, Pavo I, Mester-Tonczar J, Einzinger P, Zlabinger K Basic Res Cardiol. 2024; 119(5):807-829.

PMID: 38922408 PMC: 11461641. DOI: 10.1007/s00395-024-01064-y.

[Ga]Ga-NODAGA-E[(cRGDyK)] and [Cu]Cu-DOTATATE PET Predict Improvement in Ischemic Cardiomyopathy.

Follin B, Hoeeg C, Hunter I, Bentsen S, Juhl M, Jensen J Diagnostics (Basel). 2023; 13(2).

PMID: 36673078 PMC: 9857952. DOI: 10.3390/diagnostics13020268.

Nuclear Molecular Imaging of Cardiac Remodeling after Myocardial Infarction.

Varasteh Z, Weber W, Rischpler C Pharmaceuticals (Basel). 2022; 15(2).

PMID: 35215296 PMC: 8875369. DOI: 10.3390/ph15020183.

Multi-Scale Imaging of Vascular Pathologies in Cardiovascular Disease.

Tiwari A, Elgrably B, Saar G, Vandoorne K Front Med (Lausanne). 2022; 8:754369.

PMID: 35071257 PMC: 8766766. DOI: 10.3389/fmed.2021.754369.

Positron Emission Tomography Techniques to Measure Active Inflammation, Fibrosis and Angiogenesis: Potential for Non-invasive Imaging of Hypertensive Heart Failure.

Balogh V, MacAskill M, Hadoke P, Gray G, Tavares A Front Cardiovasc Med. 2021; 8():719031.

PMID: 34485416 PMC: 8416043. DOI: 10.3389/fcvm.2021.719031.

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