[Cutaneous Squamous Cell Carcinoma]

Overview

Journal Hautarzt

Specialty Dermatology

Date 2016 Sep 30

PMID 27680009

Citations 5

Authors

U Leiter

R Gutzmer

M Alter

C Ulrich

A S Lonsdorf

M M Sachse

U Hillen

Affiliations

Soon will be listed here.

Abstract

Squamous cell carcinoma (SCC) of the skin accounts for 20 % of non-melanoma skin cancer and is one of the most frequent types of cancer in Caucasian populations. Diagnosis is based on the clinical features and should be histopathologically confirmed to adequately address the prognosis and treatment. Complete surgical excision with histopathological control of excision margins is the gold standard in the treatment of primary SCC. Sentinel lymph node biopsies (SLNB) can be considered in SCC with a tumor thickness of >6 mm but there is currently no evidence concerning prognostic and therapeutic effects. Radiotherapy can be discussed as an alternative to surgery for inoperable tumors or as adjuvant therapy for a high risk of recurrence. In SCC with distant metastases various chemotherapeutic agents are used; however, there is no standard regimen. The epidermal growth factor receptor (EGFR) inhibitors and immune checkpoint blockers can be discussed as treatment options, preferentially in clinical trials. There is no standard follow-up schedule for patients with SCC. A risk-adapted follow-up is recommended based on the risk of metastatic spread or development of new lesions primarily by dermatological control and supplemented by ultrasound investigations in high risk patients.

Citing Articles

Actinic Keratosis and Cutaneous Squamous Cell Carcinoma.

Gutzmer R, Wiegand S, Kolbl O, Wermker K, Heppt M, Berking C Dtsch Arztebl Int. 2020; 116(37):616-626.

PMID: 32048593 PMC: 6819699. DOI: 10.3238/arztebl.2019.0616.

Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis.

Pyczek J, Khizanishvili N, Kuzyakova M, Zabel S, Bauer J, Nitzki F Front Genet. 2019; 10:1185.

PMID: 31867038 PMC: 6904360. DOI: 10.3389/fgene.2019.01185.

Long noncoding RNA LINC00520 prevents the progression of cutaneous squamous cell carcinoma through the inactivation of the PI3K/Akt signaling pathway by downregulating EGFR.

Mei X, Zhong S Chin Med J (Engl). 2019; 132(4):454-465.

PMID: 30707166 PMC: 6595718. DOI: 10.1097/CM9.0000000000000070.

miR-186 promotes tumor growth in cutaneous squamous cell carcinoma by inhibiting apoptotic protease activating factor-1.

Tian J, Shen R, Yan Y, Deng L Exp Ther Med. 2018; 16(5):4010-4018.

PMID: 30344679 PMC: 6176155. DOI: 10.3892/etm.2018.6679.

[The aged scalp : A dermato-oncological focus point].

Wroblewski N, Wylon K, Ulrich C Hautarzt. 2017; 68(6):437-444.

PMID: 28516187 DOI: 10.1007/s00105-017-3988-2.

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