Stressful Life Events and Psychosocial Correlates of Pediatric Inflammatory Bowel Disease Activity

Overview

Journal World J Psychiatry

Publisher Baishideng Publishing Group

Specialty Psychiatry

Date 2016 Sep 29

PMID 27679771

Citations 7

Authors

George Giannakopoulos

George Chouliaras

Daphne Margoni

Sophia Korlou

Vassiliki Hantzara

Ioanna Panayotou

Eleftheria Roma

Magda Liakopoulou

Dimitris C Anagnostopoulos

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate the association of psychiatric and psychosocial correlates with inflammatory bowel disease (IBD) activity in children and adolescents.

Methods: A total of 85 pediatric IBD patients (in remission or active state of the disease) and their parents completed a series of questionnaires and semi-structured interviews measuring life events, depression, anxiety, family dysfunction, and parent mental health. Differences between the remission and the IBD active group and the association of any significant variable with the disease activity state were examined.

Results: Parents of children being in active state of the disease reported more life events (P = 0.005) and stressful life events (P = 0.048) during the past year and more mental health symptoms (P < 0.001), while the children themselves reported higher levels of anxiety symptoms (P = 0.017) compared to the remission group. In the logistic regression multivariate analysis, the only predictor which had a significant positive effect on the probability of the patients being in active state was parent mental health symptoms (OR = 4.8; 95%CI: 1.2-25.8).

Conclusion: Life events, child anxiety and parent mental health symptoms may be important correlates of pediatric IBD activity and targets of thorough assessment and treatment.

Citing Articles

Evaluation of Quality of Life and Psychosocial Status in Children with Inflammatory Bowel Disease.

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Transcultural adaptation and validation of IMPACT-III and IMPACT-III-P in Spanish families: a multicenter study from SEGHNP.

Rodriguez-Belvis M, Palomino L, Pujol-Muncunill G, Martin-Masot R, Medina Benitez E, Fernandez-Lorenzo A Eur J Pediatr. 2024; 183(8):3417-3430.

PMID: 38771373 DOI: 10.1007/s00431-024-05575-7.

Anxiety, Depression, and Quality of Life in Parents of Adolescents with Inflammatory Bowel Disease: A Longitudinal Study.

Nomura S, Hirano Y, Takeuchi I, Shimizu H, Arai K Pediatr Gastroenterol Hepatol Nutr. 2023; 26(5):239-248.

PMID: 37736216 PMC: 10509017. DOI: 10.5223/pghn.2023.26.5.239.

Trajectories of psychological stress in youth across the first year of inflammatory bowel disease diagnosis.

Rea K, Cushman G, Westbrook A, Reed B J Psychosom Res. 2023; 165:111143.

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Parental Distress in Pediatric Inflammatory Bowel Diseases: Associations With Time From Diagnosis, Disease Activity, and Demographic Factors.

Cesa K, Cunningham C, Noll R, Kim S Crohns Colitis 360. 2022; 4(2):otac019.

PMID: 35783219 PMC: 9237933. DOI: 10.1093/crocol/otac019.

References

Shulman L, DeRogatis L, Spielvogel R, Miller J, Rose L . Serum androgens and depression in women with facial hirsutism. J Am Acad Dermatol. 1992; 27(2 Pt 1):178-81. DOI: 10.1016/0190-9622(92)70166-d. View

Maunder R, Levenstein S . The role of stress in the development and clinical course of inflammatory bowel disease: epidemiological evidence. Curr Mol Med. 2008; 8(4):247-52. DOI: 10.2174/156652408784533832. View

Bousvaros A, Antonioli D, Colletti R, Dubinsky M, Glickman J, Gold B . Differentiating ulcerative colitis from Crohn disease in children and young adults: report of a working group of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the Crohn's and Colitis Foundation of America. J Pediatr Gastroenterol Nutr. 2007; 44(5):653-74. DOI: 10.1097/MPG.0b013e31805563f3. View

. Inflammatory bowel disease in children and adolescents: recommendations for diagnosis--the Porto criteria. J Pediatr Gastroenterol Nutr. 2005; 41(1):1-7. DOI: 10.1097/01.mpg.0000163736.30261.82. View

Hyams J, Markowitz J, Otley A, Rosh J, Mack D, Bousvaros A . Evaluation of the pediatric crohn disease activity index: a prospective multicenter experience. J Pediatr Gastroenterol Nutr. 2005; 41(4):416-21. DOI: 10.1097/01.mpg.0000183350.46795.42. View

Gilat T, Hacohen D, Lilos P, Langman M . Childhood factors in ulcerative colitis and Crohn's disease. An international cooperative study. Scand J Gastroenterol. 1987; 22(8):1009-24. DOI: 10.3109/00365528708991950. View

Deshmukh P, Kulkarni G, Lackamp J . Inflammatory bowel disease in children: psychological and psychiatric issues. Curr Psychiatry Rep. 2010; 12(3):222-8. DOI: 10.1007/s11920-010-0111-0. View

Greenley R, Cunningham C . Parent quality of life in the context of pediatric inflammatory bowel disease. J Pediatr Psychol. 2008; 34(2):129-36. DOI: 10.1093/jpepsy/jsn056. View

Mackner L, Crandall W . Long-term psychosocial outcomes reported by children and adolescents with inflammatory bowel disease. Am J Gastroenterol. 2005; 100(6):1386-92. DOI: 10.1111/j.1572-0241.2005.41428.x. View

10.

Burke P, Kocoshis S, Chandra R, Whiteway M, Sauer J . Determinants of depression in recent onset pediatric inflammatory bowel disease. J Am Acad Child Adolesc Psychiatry. 1990; 29(4):608-10. DOI: 10.1097/00004583-199007000-00015. View

11.

CODDINGTON R . The signifance of life events as etiologic factors in the diseases of children. I. A survey of professional workers. J Psychosom Res. 1972; 16(1):7-18. DOI: 10.1016/0022-3999(72)90018-9. View

12.

Tojek T, Lumley M, Corlis M, Ondersma S, Tolia V . Maternal correlates of health status in adolescents with inflammatory bowel disease. J Psychosom Res. 2002; 52(3):173-9. DOI: 10.1016/s0022-3999(01)00291-4. View

13.

Herzer M, Denson L, Baldassano R, Hommel K . Patient and parent psychosocial factors associated with health-related quality of life in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2011; 52(3):295-9. PMC: 3058639. DOI: 10.1097/MPG.0b013e3181f5714e. View

14.

Szigethy E, Levy-Warren A, Whitton S, Bousvaros A, Gauvreau K, Leichtner A . Depressive symptoms and inflammatory bowel disease in children and adolescents: a cross-sectional study. J Pediatr Gastroenterol Nutr. 2004; 39(4):395-403. DOI: 10.1097/00005176-200410000-00017. View

15.

Kovacs M . The Children's Depression, Inventory (CDI). Psychopharmacol Bull. 1985; 21(4):995-8. View

16.

Wood B, WATKINS J, Boyle J, Nogueira J, Zimand E, Carroll L . Psychological functioning in children with Crohn's disease and ulcerative colitis: implications for models of psychobiological interaction. J Am Acad Child Adolesc Psychiatry. 1987; 26(5):774-81. DOI: 10.1097/00004583-198709000-00027. View

17.

REYNOLDS C, Richmond B . What I Think and Feel: a revised measure of Children's Manifest Anxiety. J Abnorm Child Psychol. 1997; 25(1):15-20. DOI: 10.1023/a:1025751206600. View

18.

Klein I, Reif S, Farbstein H, Halak A, Gilat T . Preillness non dietary factors and habits in inflammatory bowel disease. Ital J Gastroenterol Hepatol. 1998; 30(3):247-51. View

19.

Mackner L, Crandall W . Brief report: psychosocial adjustment in adolescents with inflammatory bowel disease. J Pediatr Psychol. 2005; 31(3):281-5. DOI: 10.1093/jpepsy/jsj023. View

20.

Steinhausen H, Kies H . Comparative studies of ulcerative colitis and Crohn's disease in children and adolescents. J Child Psychol Psychiatry. 1982; 23(1):33-42. DOI: 10.1111/j.1469-7610.1982.tb00047.x. View