Influenza Research Database: An Integrated Bioinformatics Resource for Influenza Virus Research

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 2016 Sep 29

PMID 27679478

Citations 193

Authors

Yun Zhang

Brian D Aevermann

Tavis K Anderson

David F Burke

Gwenaelle Dauphin

Zhiping Gu

Sherry He

Sanjeev Kumar

Christopher N Larsen

Alexandra J Lee

Xiaomei Li

Catherine Macken

Colin Mahaffey

Brett E Pickett

Brian Reardon

Thomas Smith

Lucy Stewart

Christian Suloway

Guangyu Sun

Lei Tong

Amy L Vincent

Bryan Walters

Sam Zaremba

Hongtao Zhao

Liwei Zhou

Christian Zmasek

Edward B Klem

Richard H Scheuermann

Affiliations

Soon will be listed here.

Abstract

The Influenza Research Database (IRD) is a U.S. National Institute of Allergy and Infectious Diseases (NIAID)-sponsored Bioinformatics Resource Center dedicated to providing bioinformatics support for influenza virus research. IRD facilitates the research and development of vaccines, diagnostics and therapeutics against influenza virus by providing a comprehensive collection of influenza-related data integrated from various sources, a growing suite of analysis and visualization tools for data mining and hypothesis generation, personal workbench spaces for data storage and sharing, and active user community support. Here, we describe the recent improvements in IRD including the use of cloud and high performance computing resources, analysis and visualization of user-provided sequence data with associated metadata, predictions of novel variant proteins, annotations of phenotype-associated sequence markers and their predicted phenotypic effects, hemagglutinin (HA) clade classifications, an automated tool for HA subtype numbering conversion, linkouts to disease event data and the addition of host factor and antiviral drug components. All data and tools are freely available without restriction from the IRD website at https://www.fludb.org.

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