Medications Influencing Central Cholinergic Neurotransmission Affect Saccadic and Smooth Pursuit Eye Movements in Healthy Young Adults

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 2016 Sep 28

PMID 27671681

Citations 4

Authors

Preshanta Naicker

Shailendra Anoopkumar-Dukie

Gary D Grant

Justin J Kavanagh

Affiliations

Soon will be listed here.

Abstract

Rationale: Acetylcholine is an important neuromodulator in the central nervous system, where it plays a significant role in central functions such as the regulation of movement.

Objective: This study investigated the pharmacological effects of over-the-counter anticholinergic medications on saccadic and smooth pursuit eye movements, in order to establish the significance of central cholinergic pathways in the control of these centrally regulated oculomotor processes.

Methods: Sixteen subjects (mean age 23 ± 3 years, 9 females) performed pro-saccadic, anti-saccadic and smooth pursuit eye movement tests, while an eye tracker collected eye movement data. Oculomotor assessments were performed pre-ingestion, 0.5 and 2 h post-ingestion of drugs with varying degrees of central anticholinergic properties. The drugs tested were promethazine, hyoscine hydrobromide, hyoscine butylbromide and placebo.

Results: The drug intervention with stronger central anticholinergic properties, promethazine, decreased amplitude and increased velocity in the pro-saccadic task and increased duration in the anti-saccadic task. Promethazine, once again, was the only drug to decrease eye velocity in the smooth pursuit test.

Conclusion: The prominent effects of the stronger central anticholinergic promethazine, on saccadic and smooth pursuit eye movements, potentially conveys the significance of central cholinergic pathways in the control of these centrally regulated oculomotor processes.

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References

Hutton S, Crawford T, Puri B, Duncan L, Chapman M, Kennard C . Smooth pursuit and saccadic abnormalities in first-episode schizophrenia. Psychol Med. 1998; 28(3):685-92. DOI: 10.1017/s0033291798006722. View

Klinkenberg I, Blokland A . The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies. Neurosci Biobehav Rev. 2010; 34(8):1307-50. DOI: 10.1016/j.neubiorev.2010.04.001. View

Klawans H, Rubovits R . Effect of cholinergic and anticholinergic agents on tardive dyskinesia. J Neurol Neurosurg Psychiatry. 1974; 37(8):941-7. PMC: 494809. DOI: 10.1136/jnnp.37.8.941. View

Kobayashi Y, Isa T . Sensory-motor gating and cognitive control by the brainstem cholinergic system. Neural Netw. 2002; 15(4-6):731-41. DOI: 10.1016/s0893-6080(02)00059-x. View

Aosaki T, Miura M, Suzuki T, Nishimura K, Masuda M . Acetylcholine-dopamine balance hypothesis in the striatum: an update. Geriatr Gerontol Int. 2010; 10 Suppl 1:S148-57. DOI: 10.1111/j.1447-0594.2010.00588.x. View

Hutton S, Crawford T, Gibbins H, Cuthbert I, Barnes T, Kennard C . Short and long term effects of antipsychotic medication on smooth pursuit eye tracking in schizophrenia. Psychopharmacology (Berl). 2001; 157(3):284-91. DOI: 10.1007/s002130100803. View

Snyder S . Action of anticholinergic drugs on striatal dopamine. Pharmacol Ther B. 1976; 2(1):65-70. DOI: 10.1016/0306-039x(76)90019-2. View

Grace P, Stanford T, Gentgall M, Rolan P . Utility of saccadic eye movement analysis as an objective biomarker to detect the sedative interaction between opioids and sleep deprivation in opioid-naive and opioid-tolerant populations. J Psychopharmacol. 2010; 24(11):1631-40. DOI: 10.1177/0269881109352704. View

Hikosaka O, Takikawa Y, Kawagoe R . Role of the basal ganglia in the control of purposive saccadic eye movements. Physiol Rev. 2000; 80(3):953-78. DOI: 10.1152/physrev.2000.80.3.953. View

10.

Baumann-Birkbeck L, Grant G, Anoopkumar-Dukie S, Kavanagh J . Drowsiness and motor responses to consecutive daily doses of promethazine and loratadine. Clin Neurophysiol. 2014; 125(12):2390-6. DOI: 10.1016/j.clinph.2014.03.026. View

11.

Glue P . Merck, Sharp & Dohme Prize for Young Psychopharmacologists: The pharmacology of saccadic eye movements. J Psychopharmacol. 2012; 5(4):377-87. DOI: 10.1177/026988119100500432. View

12.

Naicker P, Anoopkumar-Dukie S, Grant G, Kavanagh J . The effects of antihistamines with varying anticholinergic properties on voluntary and involuntary movement. Clin Neurophysiol. 2013; 124(9):1840-5. DOI: 10.1016/j.clinph.2013.04.003. View

13.

Krueger D, Michel K, Allam S, Weiser T, Demir I, Ceyhan G . Effect of hyoscine butylbromide (Buscopan®) on cholinergic pathways in the human intestine. Neurogastroenterol Motil. 2013; 25(8):e530-9. DOI: 10.1111/nmo.12156. View

14.

Walker R, Walker D, Husain M, Kennard C . Control of voluntary and reflexive saccades. Exp Brain Res. 2000; 130(4):540-4. DOI: 10.1007/s002219900285. View

15.

Picciotto M, Higley M, Mineur Y . Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior. Neuron. 2012; 76(1):116-29. PMC: 3466476. DOI: 10.1016/j.neuron.2012.08.036. View

16.

Di Stasi L, Catena A, Canas J, Macknik S, Martinez-Conde S . Saccadic velocity as an arousal index in naturalistic tasks. Neurosci Biobehav Rev. 2013; 37(5):968-75. DOI: 10.1016/j.neubiorev.2013.03.011. View

17.

Oliva G, Bucci M, Fioravanti R . Impairment of saccadic eye movements by scopolamine treatment. Percept Mot Skills. 1993; 76(1):159-67. DOI: 10.2466/pms.1993.76.1.159. View

18.

Hindmarch I, Shamsi Z, Stanley N, Fairweather D . A double-blind, placebo-controlled investigation of the effects of fexofenadine, loratadine and promethazine on cognitive and psychomotor function. Br J Clin Pharmacol. 1999; 48(2):200-6. PMC: 2014291. DOI: 10.1046/j.1365-2125.1999.00993.x. View

19.

Jo S, Hong H, Chong S, Lee H, Choe H . H(1) antihistamine drug promethazine directly blocks hERG K(+) channel. Pharmacol Res. 2009; 60(5):429-37. DOI: 10.1016/j.phrs.2009.05.008. View

20.

Yan Y, Cui D, Lynch J . Overlap of saccadic and pursuit eye movement systems in the brain stem reticular formation. J Neurophysiol. 2001; 86(6):3056-60. DOI: 10.1152/jn.2001.86.6.3056. View