Up-date on the NeoVitaA Trial: Obstacles, Challenges, Perspectives, and Local Experiences

Overview

Journal Wien Med Wochenschr

Specialty General Medicine

Date 2016 Sep 28

PMID 27671007

Citations 8

Authors

Sascha Meyer

Ludwig Gortner

Affiliations

Soon will be listed here.

Abstract

The aim of the NeoVitaA Trial is to assess the role of postnatal additional high-dose oral vitamin A supplementation for 28 days in reducing Bronchopulmonary dysplasia (BPD) or death in extremely low birth weight (ELBW) infants at 36 weeks postmenstrual age (PMA). All infants (both intervention and control group) will be provided with basic vitamin A (1000 IU/kg/day) in addition to trial intervention.In this short communication, we will give an up-date on obstacles, challenges as well as perspectives and potential solutions when putting into place a multicenter, double-blind, randomized trial in this cohort of extremely susceptible infants.

Citing Articles

Early Vitamin A Supplementation for Prevention of Short-Term Morbidity and Mortality in Very-Low-Birth-Weight Infants: A Systematic Review and Meta-Analysis.

Ye Y, Yang X, Zhao J, He J, Xu X, Li J Front Pediatr. 2022; 10:788409.

PMID: 35463913 PMC: 9021759. DOI: 10.3389/fped.2022.788409.

Supplemental Oxygen in the Newborn: Historical Perspective and Current Trends.

Mathias M, Chang J, Perez M, Saugstad O Antioxidants (Basel). 2021; 10(12).

PMID: 34942982 PMC: 8698336. DOI: 10.3390/antiox10121879.

Evidence for the Management of Bronchopulmonary Dysplasia in Very Preterm Infants.

Muehlbacher T, Bassler D, Bryant M Children (Basel). 2021; 8(4).

PMID: 33924638 PMC: 8069828. DOI: 10.3390/children8040298.

Intramuscular Followed by Oral Vitamin A Supplementation in Neonates with Birth Weight from 750 to 1250 g: A Randomized Controlled Trial.

Giridhar S, Kumar J, Attri S, Dutta S, Kumar P Indian J Clin Biochem. 2020; 35(2):197-204.

PMID: 32226251 PMC: 7093638. DOI: 10.1007/s12291-018-0807-1.

Role of Vitamin A in Mammary Gland Development and Lactation.

Cabezuelo M, Zaragoza R, Barber T, Vina J Nutrients. 2020; 12(1).

PMID: 31892157 PMC: 7019238. DOI: 10.3390/nu12010080.

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